Structure-Function Coupling in Highly Sampled Individual Brains

Rajesh, A.; Seider, N. A.; Newbold, D. J.; Adeyemo, B.; Marek, S.; Greene, D. J.; Snyder, A. Z.; Shimony, J. S.; Laumann, T. O.; Dosenbach, N. U. F.; Gordon, E. M.

doi:10.1101/2023.10.04.560909

bioRxiv · 10.1101/2023.10.04.560909

Structure-Function Coupling in Highly Sampled Individual Brains

Rajesh, A.·Seider, N. A.·Newbold, D. J.·Adeyemo, B.·Marek, S.·Greene, D. J.·Snyder, A. Z.·Shimony, J. S.·Laumann, T. O.·Dosenbach, N. U. F.·Gordon, E. M.

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Abstract

Structural connections (SC) between distant regions of the brain support synchronized function known as functional connectivity (FC) and give rise to the large-scale brain networks that enable cognition and behavior. Understanding how SC enables FC is important to understand how injuries to structural connections may alter brain function and cognition. Previous work evaluating whole-brain SC-FC relationships showed that SC explained FC well in unimodal visual and motor areas, but only weakly in association areas, suggesting a unimodal-heteromodal gradient organization of SC-FC coupling. However, this work was conducted in group-averaged SC/FC data. Thus, it could not account for inter-individual variability in the locations of cortical areas and white matter tracts. We evaluated the correspondence of SC and FC within three highly sampled healthy participants. For each participant, we collected 78 minutes of diffusion-weighted MRI for SC and 360 minutes of resting state fMRI for FC. We found that FC was best explained by SC in visual and motor systems, as well as in anterior and posterior cingulate regions. A unimodal-to-heteromodal gradient could not fully explain SC-FC coupling. We conclude that the SC-FC coupling of the anterior-posterior cingulate circuit is more similar to unimodal areas than to heteromodal areas. SIGNIFICANCE STATEMENTStructural connections between distant regions of the human brain support networked function that enables cognition and behavior. Improving our understanding of how structure enables function could allow better insight into how brain disconnection injuries impair brain function. Previous work using neuroimaging suggested that structure-function relationships vary systematically across the brain, with structure better explaining function in basic visual/motor areas than in higher-order areas. However, this work was conducted in group-averaged data, which may obscure details of individual-specific structure-function relationships. Using individual-specific densely sampled neuroimaging data, we found that in addition to visual/motor regions, structure strongly predicts function in specific circuits of the higher-order cingulate gyrus. The cingulates structure-function relationship suggests that its organization may be unique among higher-order cortical regions.

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Rajesh, A., Seider, N. A., Newbold, D. J., Adeyemo, B., Marek, S., Greene, D. J., Snyder, A. Z., Shimony, J. S., Laumann, T. O., Dosenbach, N. U. F., Gordon, E. M.. 2023-10-05. Structure-Function Coupling in Highly Sampled Individual Brains. https://doi.org/10.1101/2023.10.04.560909

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