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bioRxiv · 10.1101/2020.07.22.195719

Intra- and extra-cellular environments contribute to the fate of HIV-1 infection

Ratnapriya, S.·Harris, M.·Chov, A.·Vrbanac, V.·Deruaz, M.·Sodroski, J.·Herschhorn, A.
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Abstract

HIV-1 entry into host cells leads to one of three alternative fates: 1) HIV-1 elimination by restriction factors, 2) establishment of HIV-1 latency, or 3) active viral replication in target cells. Here we developed an improved system for monitoring HIV-1 fate and provide evidence for the differential contribution of the intracellular environment as well as extracellular environment found in organs of BLT humanized mouse to the fate of HIV-1 infection.

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Ratnapriya, S., Harris, M., Chov, A., Vrbanac, V., Deruaz, M., Sodroski, J., Herschhorn, A.. 2020-07-22. Intra- and extra-cellular environments contribute to the fate of HIV-1 infection. https://doi.org/10.1101/2020.07.22.195719

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