Biology subjects

Sodroski, J.

Publications and source records attributed to Sodroski, J..

2 recordsLinked to original sources

bioRxiv2020

Intra- and extra-cellular environments contribute to the fate of HIV-1 infection

HIV-1 entry into host cells leads to one of three alternative fates: 1) HIV-1 elimination by restriction factors, 2) establishment of HIV-1 latency, or 3) active viral replication in target cells. Here we developed an improved system for monitoring HIV-1 fate and provide evidence for the differential contribution of the intracellular environment as well as extracellular environment found in organs of BLT humanized mouse to the fate of HIV-1 infection.

microbiology↗

bioRxiv2020

SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ~5-fold and ~7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.

microbiology↗