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Pat, N.

Publications and source records attributed to Pat, N..

8 recordsLinked to original sources

Supervised Domain Adaptation Mitigates Cross-Ethnicity Prediction Error in Neuroimaging Based Cognitive Prediction

Machine learning models are increasingly used to predict cognitive and clinical outcomes from neuroimaging data, yet challenges in fairness and generalizability remain. Large scale datasets are often racially and ethnically imbalanced, leading to systematic performance disparities, with models typically achieving higher accuracy for majority populations represented in the training data. In this study, we evaluated whether supervised domain adaptation methods including balanced weighting, two-stage TrAdaBoost, feature augmentation with SrcOnly prediction, and linear interpolation can mitigate these biases. Using the ABCD dataset, we assessed whether models trained on 80 MRI measures from White American participants could generalize more effectively to African American participants. All domain adaptation methods reduced prediction error for African American participants, particularly for MRI modalities with large baseline disparities (e.g., structural MRI), while offering limited improvements where initial gaps were smaller (e.g., functional connectivity). Among the approaches, balanced weighting performed best and remained stable and beneficial even when only 10 African American participants were used to adapt the original model trained exclusively on White American participants. These findings suggest that simple, low-cost strategies can effectively reduce cross-ethnic performance gaps and improve equity in predictive neuroimaging, offering a practical path forward for future neuroimaging predictive biomarkers.

neuroscience↗

Source-space EEG functional connectivity and prediction of cognition in Parkinsons disease: No added benefit of individualized head models over standard templates

IntroductionCognitive decline is a major non-motor feature of Parkinsons disease (PD), but reliable and accessible biomarkers remain limited. Resting-state electroencephalography (EEG) is a promising candidate because it is low-cost, portable, and well suited to repeated assessment. Recent work has increasingly focused on source-space functional connectivity (FC) for the prediction of cognition. However, the influence of source modelling based on an individualized MRI-based head model relative to that based on standard template model is unknown. MethodsTo compare these two source-space EEG FC methods, we analysed EEG data from the New Zealand Parkinsons Progression Programme, including 136 people with PD and 51 age-similar controls. Source space resting-state EEG, parcellated with the HCP-MMP1 atlas, was used to derive amplitude envelope correlation (AEC) and debiased weighted phase lag index (dwPLI) across six canonical frequency bands. The resulting twenty-four FC modalities were evaluated using six machine-learning regression algorithms within a nested cross-validation framework. ResultsTheta-, alpha-, and beta-band FC showed the most consistent prediction of global cognition. The strongest performance was observed for theta- and alpha-band AEC and dwPLI features (max R{superscript 2} = 0.170, 95% CI = 0.067-0.262; max r = 0.439, 95% CI = 0.328-0.537). Standard and individualized head models showed comparable predictive performance across nearly all modalities. The feature-importance neuroanatomical patterns for Cole-Anticevic networks were also similar between the two head-model options. ConclusionsWe found that source-space resting-state EEG FC can predict cognitive performance in PD. The comparability of the two head models suggests that the more user-friendly and less resource-intensive standard template head model is sufficient for this purpose. This supports feasible, scalable, and clinically accessible EEG-based FC biomarkers of cognition in PD.

neuroscience↗

Multimodal MRI prediction of cognitive functioning across the lifespan: separating between-person differences from within-person changes

Brain MRI shows promise for predicting cognitive functioning, but its utility depends on its capacity to capture stable between-person differences (e.g., patient stratification), longitudinal within-person changes (e.g., prognosis, treatment monitoring), or both. Using longitudinal data from 450 adults (aged 21-90; up to three waves, five years apart) in the Dallas Lifespan Brain Study, we benchmarked five modalities, task fMRI, functional connectivity (FC), structural MRI (sMRI), diffusion-weighted imaging (DWI), and arterial spin labeling (ASL), across 37 phenotypes and their combination. Stacking all MRI modalities into one marker predicted cognitive functioning with the highest accuracy (R{superscript 2}=.51), followed by DWI and FC. Variance decomposition showed MRI markers explained substantial between-person variance (up to 60.3%) but modest within-person changes (up to 17.2%) in cognitive functioning. Commonality analysis revealed most markers, except ASL, overlapped with age-related variance in cognitive functioning. These findings clarify the strengths and limitations of MRI markers for stratifying and monitoring cognitive aging.

neuroscience↗

Multimodal MRI-based neuromarkers trace longitudinal changes in cognitive functioning in ADHD

The National Institute of Mental Healths Research Domain Criteria (RDoC) framework conceptualises cognition as a core functional domain for psychopathology that should be studied across multiple units of analysis and developmental timescales. In ADHD, however, it remains unclear whether neuroimaging-derived markers can not only predict inter-individual differences in cognition but also track longitudinal cognitive development and capture cognition-psychopathology relationships. Using the longitudinal Oregon ADHD-1000 study (n = 594 participants; 1,053 observations), we developed multimodal machine-learning markers of general cognitive functioning (g) from structural and resting-state functional MRI. The multimodal marker achieved an out-of-sample correlation of r = .46 and generalised similarly across children with and without ADHD. The marker explained 25.01% of interindividual variance (r = .48) and 18.82% of intraindividual variance (r = .52) in cognitive functioning. Commonality analyses showed that it captured 60.87% of intraindividual age-related cognitive variation (5.18% of the total variance in g). The marker also accounted for substantial portions of the cognition-hyperactivity association (58.79%; 6.39% of total variance in g) and the cognition-inattention association (25.99%; 4.13% of total variance in g). These findings provide evidence that multimodal structural and functional MRI can generate RDoC-informed markers that predict cognitive functioning, track cognitive development over time, and capture meaningful links between cognition and ADHD symptoms. Although predictive performance remains below levels required for clinical application, the results establish a foundation for longitudinal, RDoC-inspired investigations of cognitive development in ADHD.

neuroscience↗

When Brain Models Are not Universal: Benchmarking of Ethnic Bias in MRI-Based Cognitive Prediction Across Modalities

Predictive neuroimaging models promise precision medicine but risk exacerbating health inequities if they perform unevenly across ethnic/racial groups. Using the Adolescent Brain Cognitive Development data, we benchmarked ethnic/racial bias in models predicting cognitive functioning from 91 MRI phenotypes across four training strategies. Models trained on one ethnicity performed best within that group. Models trained on participants sampled without regard to ethnicity, a common practice, performed better on White participants, likely because the ABCD sample was predominantly White. Training on equal-sized White and African American subsamples reduced disparities without accuracy loss, emerging as the upper bound for both accuracy and fairness. Structural MRI exhibited the greatest bias, whereas task-based fMRI phenotypes were more equitable. Stronger brain-cognition associations generalized more equitably, but multimodal stacking--despite enhancing prediction--did not improve fairness. Increasing representation of African American participants improved performance up to balanced sampling, with diminishing returns beyond. This first modality-wide benchmark reveals pervasive, modality-dependent ethnic bias in cognitive prediction and identifies key factors shaping equity in neuroimaging models.

neuroscience↗

Improving Predictability, Test-Retest Reliability and Generalisability of Brain-Wide Associations for Cognitive Abilities via Multimodal Stacking

Brain-wide association studies (BWASs) have attempted to relate cognitive abilities with brain phenotypes, but have been challenged by issues such as predictability, test-retest reliability, and cross-cohort generalisability. To tackle these challenges, we proposed a machine-learning "stacking" approach that draws information from whole-brain magnetic resonance imaging (MRI) across different modalities, from task-fMRI contrasts and functional connectivity during tasks and rest to structural measures, into one prediction model. We benchmarked the benefits of stacking, using the Human Connectome Projects: Young Adults (n=873, 22-35 years old) and Human Connectome Projects-Aging (n=504, 35-100 years old) and the Dunedin Multidisciplinary Health and Development Study (Dunedin Study, n=754, 45 years old). For predictability, stacked models led to out-of-sample r[~].5-.6 when predicting cognitive abilities at the time of scanning, primarily driven by task-fMRI contrasts. Notably, using the Dunedin Study, we were able to predict participants cognitive abilities at ages 7, 9, and 11 using their multimodal MRI at age 45, with an out-of-sample r of 0.52. For test-retest reliability, stacked models reached an excellent level of reliability (ICC>.75), even when we stacked only task-fMRI contrasts together. For generalisability, a stacked model with non-task MRI built from one dataset significantly predicted cognitive abilities in other datasets. Altogether, stacking is a viable approach to undertake the three challenges of BWAS for cognitive abilities. Significance statementScientists have had limited success in predicting cognitive abilities from brain MRI. We proposed a machine learning method, called stacking, to draw information across different types of brain MRI. Using three large databases (n=2,131, 22-100 years old), we found stacking to make the prediction of cognitive abilities 1) closer to actual cognitive scores when applied to a new individual, not part of the modelling process, 2) reliable over times and 3) applicable to the data collected from different age groups and MRI scanners. Indeed, stacking, especially with fMRI task contrasts, allowed us to use MRI of people aged 45 to predict their childhood cognitive abilities reasonably well. Accordingly, stacking may help MRI realise its potential to predict cognitive abilities.

neuroscience↗

The (Limited?) Utility of Brain Age as a Biomarker for Capturing Cognitive Decline

Fluid cognition usually declines as people grow older. For decades, neuroscientists have been on a quest to search for a biomarker that can help capture fluid cognition. One well-known candidate is Brain Age, or a predicted value based on machine-learning models built to predict chronological age from brain MRI data. Here we aim to formally evaluate the utility of Brain Age as a biomarker for capturing fluid cognition among older individuals. Using 504 aging participants (36-100 years old) from the Human Connectome Project in Aging, we created 26 age-prediction models for Brain Age based on different combinations of MRI modalities. We first tested how much Brain Age from these age-prediction models added to what we had already known from a persons chronological age in capturing fluid cognition. Based on the commonality analyses, we found a large degree of overlap between Brain Age and chronological age, so much so that, at best, Brain Age could uniquely add only around 1.6% in explaining variation in fluid cognition. Next, the age-prediction models that performed better at predicting chronological age did NOT necessarily create better Brain Age for capturing fluid cognition over and above chronological age. Instead, better-performing age-prediction models created Brain Age that overlapped larger with chronological age, up to around 29% out of 32%, in explaining fluid cognition, thus not improving the models utility to capture cognitive abilities. Lastly, we tested how much Brain Age missed the variation in the brain MRI that could explain fluid cognition. To capture this variation in the brain MRI that explained fluid cognition, we computed Brain Cognition, or a predicted value based on prediction models built to directly predict fluid cognition (as opposed to chronological age) from brain MRI data. We found that Brain Cognition captured up to an additional 11% of the total variation in fluid cognition that was missing from the model with only Brain Age and chronological age, leading to around a 1/3-time improvement of the total variation explained. Accordingly, we demonstrated the limited utility of Brain Age as a biomarker for fluid cognition and made some suggestions to ensure the utility of Brain Age in explaining fluid cognition and other phenotypes of interest.

neuroscience↗

Integrating Task-Based Functional MRI Across Tasks Markedly Boosts Prediction and Reliability of Brain-Cognition Relationship

Capturing individual differences in cognition is central to human neuroscience. Yet our ability to estimate cognitive abilities via brain MRI is still poor in both prediction and reliability. Our study tested if this inability can be improved by integrating MRI signals across the whole brain and across modalities, including task-based functional MRI (tfMRI) of different tasks along with other non-task MRI modalities, such as structural MRI, resting-state functional connectivity. Using the Human Connectome Project (n=873, 473 females, after quality control), we directly compared predictive models comprising different sets of MRI modalities (e.g., seven tasks vs. non-task modalities). We applied two approaches to integrate multimodal MRI, stacked vs. flat models, and implemented 16 combinations of machine-learning algorithms. The stacked model integrating all modalities via stacking Elastic Net provided the best prediction (r=.57), relatively to other models tested, as well as excellent test-retest reliability (ICC=~.85) in capturing general cognitive abilities. Importantly, compared to the stacked model integrating across non-task modalities (r=.27), the stacked model integrating tfMRI across tasks led to significantly higher prediction (r=.56) while still providing excellent test-retest reliability (ICC=~.83). The stacked model integrating tfMRI across tasks was driven by frontal and parietal areas and by tasks that are cognition-related (working-memory, relational processing, and language). This result is consistent with the parieto-frontal integration theory of intelligence. Accordingly, our results contradict the recently popular notion that tfMRI is not reliable enough to capture individual differences in cognition. Instead, our study suggests that tfMRI, when used appropriately (i.e., by drawing information across the whole brain and across tasks and by integrating with other modalities), provides predictive and reliable sources of information for individual differences in cognitive abilities, more so than non-task modalities. HighlightsO_LINon-task MRI (sMRI, rs-fMRI) are often used for the brain-cognition relationship. C_LIO_LITask-based fMRI has been deemed unreliable for capturing individual differences. C_LIO_LIWe tested if drawing task-based fMRI information across regions/tasks improves prediction and reliability of the brain-cognition relationship. C_LIO_LIOur approach boosts prediction of task-based fMRI over non-task MRI. C_LIO_LIOur approach renders task-based fMRI reliable over time. C_LIO_LIOur approach shows the importance of the fronto-parietal areas in cognition. C_LI

neuroscience↗