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bioRxiv · 10.64898/2026.07.09.737533

Neurobehavioural correlates of changing one's mind in ADHD and OCD

Zuhlsdorff, K.·Dalley, J. W.·Robbins, T.·Morein-Zamir, S.
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Abstract

Cognitive flexibility is an executive function that allows individuals to adjust behaviour in response to changing environmental demands. We assessed volitional switching under uncertainty, without rule-based learning, in the Change Your Mind task. Nineteen patients with obsessive-compulsive disorder (OCD), 19 patients with attention-deficit hyperactivity disorder (ADHD) and matched control participants (20 per group) completed the task whilst undergoing a functional MRI scan. The task was a two-alternative forced choice paradigm where each stimulus was presented twice successively, with spurious feedback following the first presentation. This allowed participants the opportunity to repeat or change their response. Participants with ADHD changed their response more frequently than controls following a previously correct response, associated with reduced accuracy on the second trial. This was accompanied with smaller differences between change and repeat trials in the superior frontal gyrus, paracingulate gyrus and frontal pole compared to controls. Participants with OCD did not differ from healthy controls in their performance but exhibited greater activity on both change and repeat trials in the pre- and postcentral gyri than controls. These results point to distinct neurobehavioural differences in patients with ADHD and OCD underlying what is often termed more broadly inflexible behaviour.

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Zuhlsdorff, K., Dalley, J. W., Robbins, T., Morein-Zamir, S.. 2026-07-15. Neurobehavioural correlates of changing one's mind in ADHD and OCD. https://doi.org/10.64898/2026.07.09.737533

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