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bioRxiv · 10.64898/2026.05.01.722269

Aptamer-based DNA nanoswitches for multiplexed protein detection

Kovvali, S.·Beckles, C. A.·Chandrasekaran, A. R.·Halvorsen, K.
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Abstract

Simple, modular platforms for detecting biologically relevant proteins are critical for applications in clinical diagnostics, healthcare, and research. Here, we have combined aptamer-based protein recognition with our conformationally-responsive DNA nanoswitches to enable simple, sensitive and specific protein detection. We demonstrate dual detection of two clinically relevant blood proteins, thrombin and VEGF as initial proof of concept.

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Kovvali, S., Beckles, C. A., Chandrasekaran, A. R., Halvorsen, K.. 2026-05-05. Aptamer-based DNA nanoswitches for multiplexed protein detection. https://doi.org/10.64898/2026.05.01.722269

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