A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets

Abstract

ObjectiveMany deep brain stimulation (DBS) systems sense local field potentials (LFPs) for patient monitoring or closed-loop therapy (CL-DBS). LFPs can be impacted by artifacts, including a recently discovered cardiac non-electrocardiographic pulse signal that can be visually masked by commercial device filters. We aimed to establish its prevalence across patient groups and brain areas, and to investigate its spectral impact. MethodsWe performed a cross-sectional analysis of LFPs recorded from the cranially mounted Picostim from the pedunculopontine nucleus in multiple systems atrophy patients, periacqueductal gray and sensory thalamus in chronic pain patients, and the centromedian thalamic nucleus (CMT) in paediatric epilepsy patients. For comparison, we analyse externalised recordings from the subthalamic nucleus in Parkinsons disease patients. The PulsAr algorithm was developed to detect and extract pulsatile signals, and we characterised contamination level and spectral content. ResultsThough not visually obvious in CMT, the pulsatile signal was algorithmically detected in all targets, with 33% of LFPs across targets classed as contaminated. Pulse signal power was similar across targets and may have been masked by higher endogenous activity in CMT. While its dominant frequencies were in the heartbeat range, the signal had spectral content extending up to >10Hz. ConclusionsA heart pulse signal affects LFP recordings from DBS leads across brain regions and patient groups. While masked by some device filters, spectral content can extend into higher (clinically relevant) frequencies. Researchers and clinicians should exercise caution when sensing lower LFP frequencies, especially for automated control of therapy in CL-DBS. HighlightsO_LIHistorically, electrocardiographic artifacts have been a major source of artifact affecting deep brain stimulation recordings, however pulsatile artifact is less well described. C_LIO_LIA cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets. C_LIO_LIWe introduce an ECG-independent algorithm that detects and extracts this pulsatile signal. C_LIO_LIThe heart pulse signal looks like the intracranial pressure waveform and affects spectral frequencies above the heart rate range up to >10Hz. C_LIO_LIClinicians should incorporate screening and procedures to ensure accurate biomarker detection for clinical decision making. C_LI