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bioRxiv · 10.64898/2026.01.26.701529

A comprehensive resource on chemicals used in aquaculture and their ecotoxicity

Madgaonkar, S. R.·Vashishth, S.·Chivukula, N.·Garisetti, V.·Marigoudar, S. R.·Sharma, K. V.·Samal, A.
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Abstract

Sustainable aquaculture requires comprehensive chemical oversight, as compounds used in aquaculture can persist in ecosystems, bioaccumulate through food chains, and affect aquatic life and human health. This study presents ReCAnt (Resource on Chemicals used in Aquaculture and their Ecotoxicity), which compiles information on 690 aquaculture chemicals, with data on toxic effects and therapeutic potential curated from published literature. It was observed that only a fraction of the 690 chemicals are currently regulated, revealing gaps in existing regulations. Integration of data from the Comparative Toxicogenomics Database revealed associations with genes, phenotypes, and diseases, while ECOTOX data provided toxicity and bioconcentration information. Predicted biotransformation pathways and partition coefficients indicated microbial degradation potential and fate across environmental media. Further, food web network analysis identified species vulnerable to trophic transfer and common entry points for chemicals into aquatic ecosystems. This resource can aid in developing evidence-based regulatory frameworks and promoting sustainable chemical management.

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Madgaonkar, S. R., Vashishth, S., Chivukula, N., Garisetti, V., Marigoudar, S. R., Sharma, K. V., Samal, A.. 2026-01-28. A comprehensive resource on chemicals used in aquaculture and their ecotoxicity. https://doi.org/10.64898/2026.01.26.701529

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