Biology subjects

Vashishth, S.

Publications and source records attributed to Vashishth, S..

4 recordsLinked to original sources

bioRxiv2026

NANHA - Neurostimulation in Atypical Neurodevelopment: a Harmonized Atlas

Non-invasive brain stimulation (NIBS) has become an important tool for investigating brain function and exploring therapeutic intervention in neurodevelopmental disorders (NDDs). Nevertheless, relevant studies are scattered across different NDDs, stimulation modalities, target regions, and experimental designs, which makes systematic exploration and comparative analysis challenging. Therefore, we present NANHA, a manually curated, harmonized and freely accessible resource of published NIBS studies in NDDs. The database was constructed using systematic PubMed searches covering 22 NDDs and five NIBS modalities. NANHA captures participant characteristics, study design, stimulation purpose and parameters, targeted brain regions, behavioral, cognitive, and neurophysiological outcomes, safety information, and follow-up assessments, whenever available. The NANHA web platform (https://cb.imsc.res.in/nanha/) provides searchable and downloadable records, advanced filtering options, and interactive visualizations to support data exploration. Overall, NANHA is a standardized resource for evidence synthesis, comparative analyses, identification of research gaps, and the development of disease-specific stimulation protocols for NDDs.

neuroscience↗

bioRxiv2026

TickMapKB: A FAIR Spatial Knowledgebase of Tick Species and Associated Pathogens in India

Ticks transmit pathogens across wildlife, domestic animals, and humans, and are therefore considered important vectors under the One Health framework. In India, the burden of tick-borne diseases, such as Kyasanur Forest Disease and Crimean-Congo Hemorrhagic Fever, remains poorly quantified due to fragmented surveillance and limited spatial data. Here, we present TickMapKB, a curated spatial knowledgebase documenting 72 tick species across more than 600 georeferenced locations in India. The majority of the species belonged to the genera Haemaphysalis, Rhipicephalus, and Hyalomma. Additionally, the resource integrates host associations, pathogen and disease information, morphological identification keys, acaricide resistance profiles, and protein annotations into a single, interactive platform accessible at https://cb.imsc.res.in/tickmapkb/. Specifically, the resource captures 53 pathogens, over 3000 protein annotations, and morphological keys from 26 published resources. TickMapKB thus provides researchers, clinicians, and other stakeholders with integrated spatial, biological, and resistance information to support surveillance planning, resistance management, and tick-borne disease risk assessment.

ecology↗

bioRxiv2026

A comprehensive resource on chemicals used in aquaculture and their ecotoxicity

Sustainable aquaculture requires comprehensive chemical oversight, as compounds used in aquaculture can persist in ecosystems, bioaccumulate through food chains, and affect aquatic life and human health. This study presents ReCAnt (Resource on Chemicals used in Aquaculture and their Ecotoxicity), which compiles information on 690 aquaculture chemicals, with data on toxic effects and therapeutic potential curated from published literature. It was observed that only a fraction of the 690 chemicals are currently regulated, revealing gaps in existing regulations. Integration of data from the Comparative Toxicogenomics Database revealed associations with genes, phenotypes, and diseases, while ECOTOX data provided toxicity and bioconcentration information. Predicted biotransformation pathways and partition coefficients indicated microbial degradation potential and fate across environmental media. Further, food web network analysis identified species vulnerable to trophic transfer and common entry points for chemicals into aquatic ecosystems. This resource can aid in developing evidence-based regulatory frameworks and promoting sustainable chemical management.

pharmacology and toxicology↗

bioRxiv2026

DEDuCT 3.0: An enhanced and expanded FAIR-compliant resource and toxicology knowledge graph for endocrine disrupting chemicals

Endocrine disrupting chemicals (EDCs) are of particular regulatory and research interest due to the increasing incidence of endocrine-related disorders, such as declining fertility rates and reproductive health problems. The Database of Endocrine Disrupting Chemicals and their Toxicity Profiles (DEDuCT) has gained importance in both academic and regulatory settings by systematically curating data from published literature to characterize these chemicals. Given the growing body of EDC literature, this study aimed to consolidate the latest research and update this critical database. First, more than 14000 research articles were screened through an extensive four-stage manual process, and integrated with the earlier version to create the updated DEDuCTv3.0, comprising 1043 unique EDCs and 796 unique endocrine-related endpoints curated from 3269 published articles. Thereafter, human- and rodent-specific biological endpoint data including interacting genes/proteins, phenotypes, diseases, and adverse outcome pathways (AOPs) were curated from toxicology-relevant databases and systematically integrated with DEDuCTv3.0 to construct a large-scale toxicology knowledge graph for EDCs, termed DEDuCT-KG. DEDuCT-KG was then hosted on a Neo4j database and made easily accessible through a novel interactive user interface. The utility of DEDuCT-KG was demonstrated by exploring potential mechanisms of action associated with obesogenic EDCs within DEDuCTv3.0. Furthermore, the constructed EDC-AOP network, linking 949 EDCs to 381 AOPs within AOP-Wiki, revealed diverse toxicity mechanisms associated with EDCs. Integration with consumer product database and regulatory chemical lists showed that some of these EDCs are present in food contact materials, personal care products, and daily use items, highlighting potential exposure pathways. Overall, all data compiled in this study have been integrated into the DEDuCT webserver, which has been further enhanced to align with FAIR principles. In sum, this study provides a much-needed update to DEDuCT and offers a single point of access to EDC-relevant data to accelerate research and regulation of EDCs.

pharmacology and toxicology↗