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bioRxiv · 10.64898/2026.01.08.698416

circDiscoverer: A resource for curated and predicted circRNA-Protein interactions with experimental support tools

Srinivasan, S.·Kumar, S.·Chatterjee, S.·Chande, A.
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Abstract

Circular RNAs (circRNAs) regulate various cellular processes by interacting with miRNAs, proteins, and by encoding peptides. Compared to circRNA-miRNA interactions, circRNA-protein interactions (CPIs) and circRNA modifications have been relatively less explored. Here, we developed a comprehensive user-friendly web resource, CircDiscoverer, to explore CPIs and modification landscapes across multiple species, including Homo sapiens, Mus musculus, Drosophila melanogaster, and Arabidopsis thaliana. CircDiscoverer integrates manually curated literature-supported CPIs with computationally predicted interactions. Furthermore, it offers comprehensive insights into protein-binding profiles and detailed information on interacting circRNAs, including qRT-PCR primer sequences, guide RNAs for experimental validation and potential RNA modifications, thereby providing an integrated platform for further research. CircDiscoverer is available at https://aclab.iiserb.ac.in.

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Srinivasan, S., Kumar, S., Chatterjee, S., Chande, A.. 2026-01-09. circDiscoverer: A resource for curated and predicted circRNA-Protein interactions with experimental support tools. https://doi.org/10.64898/2026.01.08.698416

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