Languages of the brain: fMRI dissection of the amodal networks for language, mathematics, and social knowledge

Abstract

The ability to compose complex mental representations by recombining simpler primitives is a characteristic of the human brain that manifests itself in a variety of domains such as spoken or written language, mathematics, or social reasoning. While it is known that these domains rest on partially distinct brain networks, they are rarely investigated together in the same paradigm. Here, we present a systematic functional MRI study of written and spoken word and sentence processing in each of these domains. In a true-false judgment task, adult participants were presented with a hierarchy of meaningless and meaningful stimuli bearing on various domains of general semantic knowledge and mathematics. The results show that distinct brain regions are activated by (1) syntax and semantics; (2) math versus non-math knowledge; (3) different domains of mathematics, such as geometry versus arithmetic; (4) social knowledge versus other knowledge. All of these regions are activated essentially identically in the written and spoken modalities. The results were replicated in a group of adolescents. Our experiments show that the human brain comprises distinct amodal networks for various domains of linguistic and semantic knowledge, and provide a simple paradigm to dissect them within a short fMRI session.