An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

Sayed, N.; Gao, T.; Tibshirani, R. j.; Hastie, T.; Cui, L.; Kuznetsova, T.; Rosenberg-Hasson, Y.; Ostan, R.; Monti, D.; Lehallier, B.; Shen-Orr, S.; Maecker, H.; Dekker, C. L.; Wyss-Coray, T.; Franceschi, C.; Jojic, V.; Haddad, F.; Montoya, J. G.; Wu, J. C.; Furman, D.

doi:10.1101/840363

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bioRxiv · 10.1101/840363

An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

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Abstract

While many diseases of aging have been linked to the immunological system, immune metrics with which to identify the most at-risk individuals are lacking. Here, we studied the blood immunome of 1001 individuals age 8-96 and derived an inflammatory clock of aging (iAge), which tracked with multi-morbidity and immunosenescence. In centenarians, iAge was on average, 40 years lower than their corresponding chronological age. The strongest contributor to this metric was the chemokine CXCL9, which was involved in cardiac aging, affected vascular function, and down-regulated Sirtuin-3, a longevity-associated molecule. Thus, our results identify an important link between inflammatory molecules and pathways known to govern lifespan.

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Sayed, N., Gao, T., Tibshirani, R. j., Hastie, T., Cui, L., Kuznetsova, T., Rosenberg-Hasson, Y., Ostan, R., Monti, D., Lehallier, B., Shen-Orr, S., Maecker, H., Dekker, C. L., Wyss-Coray, T., Franceschi, C., Jojic, V., Haddad, F., Montoya, J. G., Wu, J. C., Furman, D.. 2019-11-16. An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans. https://doi.org/10.1101/840363

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