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bioRxiv · 10.1101/591131

Differential expression of the T cell inhibitor TIGIT in Glioblastoma and Multiple Sclerosis

Lucca, L. E.·Lerner, B. A.·DeBartolo, D.·Park, C.·Ponath, G.·Raddassi, K.·Hafler, D. A.·Pitt, D.
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Abstract

To identify co-inhibitory immune pathways important in the brain, we hypothesized that comparison of T cells in lesions from patients with MS with tumor infiltrating T cells (TILs) from patients with GBM may reveal novel targets for immunotherapy. Focusing on PD-1 and TIGIT, we found that TIGIT and its ligand CD155 were highly expressed on GBM TILs but were near-absent in MS lesions, while lymphocytic expression of PD-1/PDL-1 was comparable. TIGIT was also upregulated in peripheral lymphocytes in GBM, suggesting recirculation of TILs. These data raise the possibility that anti-TIGIT therapy may be beneficial for patients with glioblastoma.

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Lucca, L. E., Lerner, B. A., DeBartolo, D., Park, C., Ponath, G., Raddassi, K., Hafler, D. A., Pitt, D.. 2019-03-27. Differential expression of the T cell inhibitor TIGIT in Glioblastoma and Multiple Sclerosis. https://doi.org/10.1101/591131

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