Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem

Nizzero, S.; Alfonso, J. C. L.; Alvarez-Arenas, A.; Mirzaev, I.; Zervantonakis, I. K.; Lewin, T.; Rishi, A.; Piretto, E.; Joshi, T. V.; Santiago, D. N.; Karolak, A. M.; Howard, R.; Enderling, H.; Karreth, F. A.; Torres-Roca, J.

doi:10.1101/458372

bioRxiv · 10.1101/458372

Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem

Nizzero, S.·Alfonso, J. C. L.·Alvarez-Arenas, A.·Mirzaev, I.·Zervantonakis, I. K.·Lewin, T.·Rishi, A.·Piretto, E.·Joshi, T. V.·Santiago, D. N.·Karolak, A. M.·Howard, R.·Enderling, H.·Karreth, F. A.·Torres-Roca, J.

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Abstract

Non-small-cell lung cancer is the leading cause of cancer death worldwide. Although radiotherapy is an effective treatment choice for early-stage cases, the 5-year survival rate of patients diagnosed in late-stages remains poor. Increasing evidence suggests that the local and systemic effects of radiotherapy dependent on the induced anti-tumor immune responses. We believe that an educated adaptation of radiotherapy plans based not only on the induced immune responses, but also on the tumor-immune ecosystem composition at the beginning of treatment might increase local tumor control. We propose two different mathematical models to evaluate the potential of the tumor-immune context to inform adaptation of treatment plans with the aim of improving outcomes.

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Nizzero, S., Alfonso, J. C. L., Alvarez-Arenas, A., Mirzaev, I., Zervantonakis, I. K., Lewin, T., Rishi, A., Piretto, E., Joshi, T. V., Santiago, D. N., Karolak, A. M., Howard, R., Enderling, H., Karreth, F. A., Torres-Roca, J.. 2018-11-08. Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem. https://doi.org/10.1101/458372

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