Biology subjects

Mirzaev, I.

Publications and source records attributed to Mirzaev, I..

2 recordsLinked to original sources

bioRxiv2018

Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem

Non-small-cell lung cancer is the leading cause of cancer death worldwide. Although radiotherapy is an effective treatment choice for early-stage cases, the 5-year survival rate of patients diagnosed in late-stages remains poor. Increasing evidence suggests that the local and systemic effects of radiotherapy dependent on the induced anti-tumor immune responses. We believe that an educated adaptation of radiotherapy plans based not only on the induced immune responses, but also on the tumor-immune ecosystem composition at the beginning of treatment might increase local tumor control. We propose two different mathematical models to evaluate the potential of the tumor-immune context to inform adaptation of treatment plans with the aim of improving outcomes.

immunology↗

bioRxiv2018

egtplot: A Python Package for 3-Strategy Evolutionary Games

1. Introduction 1. Introduction 2. Function Arguments 3. Illustrative Examples 4. Parameter Sweeps 5. Animations References Evolutionary game theory is a reformulation of classical game theory wherein the players of the game are members of a population. These members do not choose a strategy, but instead are born with their strategy ingrained--they cannot change strategy during the game. In biological terms, the strategies might represent discrete species or genotypes, hawks and doves being a classic example. Payoffs the players gain or lose based on their interactions with other players increase or decrease their fitness, thereby influencing the number or proportion of members playing that strategy in the next generation. As such, the populations of strategies can wax and wane as they outcompete or are outcompete ...

evolutionary biology↗