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bioRxiv · 10.1101/428730

Modular dynamics of DNA co-methylation networks exposes the functional organization of colon cancer cells’ genome

Mallona, I.·Ausso, S.·Diez-Villanueva, A.·Moreno, V.·Peinado, M. A.
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Abstract

Epigenomic plasticity is interconnected with chromatin structure and gene regulation. In tumor progression, orchestrated remodeling of genome organization accompanies the acquisition of malignant properties. DNA methylation, a key epigenetic mark extensively altered in cancer, is also linked to genome architecture and function. Based on this association, we postulate that the dissection of long-range co-methylation structure unveils cancer cells genome architecture remodeling. We applied network-modeling of DNA methylation co-variation in two colon cancer cohorts and found abundant and consistent transchromosomal structures in both normal and tumor tissue. Normal-tumor comparison indicated substantial remodeling of the epigenome covariation and revealed novel genomic compartments with a unique signature of DNA methylation rank inversion.

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Mallona, I., Ausso, S., Diez-Villanueva, A., Moreno, V., Peinado, M. A.. 2018-09-27. Modular dynamics of DNA co-methylation networks exposes the functional organization of colon cancer cells’ genome. https://doi.org/10.1101/428730

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