Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects

Wang, X.; Rumpel, H.; Baskaran, M.; Tun, T. A.; Strouthidis, N.; Perera, S. A.; Nongpiur, M. E.; Lim, W. E. H.; Aung, T.; Milea, D.; Girard, M. J. A.

doi:10.1101/397570

bioRxiv · 10.1101/397570

Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects

Wang, X.·Rumpel, H.·Baskaran, M.·Tun, T. A.·Strouthidis, N.·Perera, S. A.·Nongpiur, M. E.·Lim, W. E. H.·Aung, T.·Milea, D.·Girard, M. J. A.

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Abstract

PurposeTo assess the difference in optic nerve tortuosity during eye movements and globe proptosis between primary open angle glaucoma and normal subjects using orbital magnetic resonance imaging.\n\nMethods10 Chinese subjects matched for age, ethnicity and refractive errors were recruited, including five normal controls and five patients with primary open angle glaucoma. All subjects underwent magnetic resonance imaging to assess their optic nerves and globes for three eye positions: primary gaze, adduction and abduction. Optic nerve tortuosity (optic nerve length divided by the distance between two ends) and globe proptosis (maximum distance between cornea and interzygomatic line) were measured from magnetic resonance imaging images.\n\nResultsIn adduction, the tortuosity of normal eyes was significantly larger than that of the glaucomatous eyes. Optic nerve tortuosity in adduction in the control and glaucoma groups were 1.004{+/-}0.003 (mean {+/-} standard deviation) and 1.001{+/-}0.001, respectively (p=0.037). Globe proptosis (primary gaze) in glaucoma subjects (19.14{+/-}2.11 mm) was significantly higher than that in control subjects (15.32{+/-}2.79 mm; p = 0.046).\n\nConclusionsIn this sample, subjects with glaucoma exhibited more taut optic nerves and more protruding eye globes compared to normal eyes. This may impact optic nerve head deformations in anatomically predisposed patients.\n\nPrecisEyes with glaucoma have tauter optic nerves compared with normal eyes, which may exert more force on the optic nerve head tissues during eye movements.

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Wang, X., Rumpel, H., Baskaran, M., Tun, T. A., Strouthidis, N., Perera, S. A., Nongpiur, M. E., Lim, W. E. H., Aung, T., Milea, D., Girard, M. J. A.. 2018-08-22. Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects. https://doi.org/10.1101/397570

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