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bioRxiv · 10.1101/277038

Voxel-wise T2 relaxometry of Normal Pediatric Brain Development in 326 healthy infants and toddlers.

Fonov, V.·Leppert, I. R.·Pike, B.·Collins, D. L.·Brain Development Cooperative Group,
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Abstract

Quantitative T2 data from an NIH-sponsored multi-center study of Normal Brain Development was used to perform automatic voxel-wise analysis of the changes in T2 evolution in the brain in healthy children within the age range from birth to 5 years. All data were non-linearly registered into a common coordinate space. The T2 parameters were estimated by 2 point fitting from the PD-weighted and T2-weighted image data, or by least-squares fitting of 4 data points when addition intermediate weighting images were available. The main result of this study is voxel-level map of monoexponential evolution of T2 in this age range indicating the delay (in months) and the rate (in 1/months) of development. The automatic maps are compared to manual region-of-interest based estimates of T2 evolution.

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Fonov, V., Leppert, I. R., Pike, B., Collins, D. L., Brain Development Cooperative Group,. 2018-03-05. Voxel-wise T2 relaxometry of Normal Pediatric Brain Development in 326 healthy infants and toddlers.. https://doi.org/10.1101/277038

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