Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium

Dzinalija, N.; van den Heuvel, O. A.; Simpson, H. B.; Ivanov, I.; Araujo, A.; Balachander, S.; Beucke, J.; Brandeis, D.; Brem, S.; Bruin, W.; Buitelaar, J.; Castelo-Branco, M.; Choi, S.; Eng, G. K.; Fitzsimmons, S. M. D. D.; Fortea, L.; Fullana, M. A.; Grutzmann, R.; Hansen, B.; Huijser, C.; de Joode, N. T.; Kathmann, N.; Kaufmann, C.; Kim, M.; Koch, K.; Kwon, J. S.; Lim, J. X.; Martinez-Zalacain, I.; Menchon, J. M.; van de Mortel, L. A.; Narayanaswamy, J. C.; Ousdal, O. T.; Postma, T. S.; Rodriguez-Manrique, D.; van Rooij, D.; Shivakumar, V.; Soriano-Mas, C.; Stern, E. R.; Thomopoulos, S. I.

doi:10.1101/2025.10.22.683868

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bioRxiv · 10.1101/2025.10.22.683868

Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium

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Abstract

ObjectiveObsessive-compulsive disorder (OCD) is a chronic condition in which impaired inhibitory control and excessive error monitoring may contribute to the maintenance of obsessions and compulsions. This mega-analysis investigates neural activation during response inhibition and error processing using adult and pediatric data from the ENIGMA-OCD consortium and the ABCD study. MethodsIndividual participant data was uniformly processed using HALFpipe to extract statistical maps for response inhibition and error processing contrasts. Bayesian multilevel models were used to assess regional and whole-brain effects of OCD, with additional analyses examining the association between the OCD clinical profile and task-related activation. ResultsAcross inhibitory control tasks, both individuals with OCD and control participants showed robust activation in regions implicated in response inhibition and error processing. During response inhibition, compared to controls, adults with OCD showed stronger somatomotor cortex activation, while children with OCD showed stronger occipital cortex activation. Children with likely OCD from the ABCD cohort showed reduced activity in the frontoparietal network in the anterior insula/frontal operculum region. During error processing, relative to controls, adults with OCD showed weaker activation in fronto-striatal regions, while children with OCD showed stronger activation in frontoparietal and attention networks. Greater OCD symptom severity was associated with weaker task-related activation in adults and stronger activation in children during response inhibition. ConclusionCase-control differences in brain activation during inhibitory control varied by age group and task contrast. Symptom severity emerged as the main clinical correlate of activation during inhibition, suggesting that inhibitory control deficits in OCD may be both state-dependent and developmentally specific.

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Dzinalija, N., van den Heuvel, O. A., Simpson, H. B., Ivanov, I., Araujo, A., Balachander, S., Beucke, J., Brandeis, D., Brem, S., Bruin, W., Buitelaar, J., Castelo-Branco, M., Choi, S., Eng, G. K., Fitzsimmons, S. M. D. D., Fortea, L., Fullana, M. A., Grutzmann, R., Hansen, B., Huijser, C., de Joode, N. T., Kathmann, N., Kaufmann, C., Kim, M., Koch, K., Kwon, J. S., Lim, J. X., Martinez-Zalacain, I., Menchon, J. M., van de Mortel, L. A., Narayanaswamy, J. C., Ousdal, O. T., Postma, T. S., Rodriguez-Manrique, D., van Rooij, D., Shivakumar, V., Soriano-Mas, C., Stern, E. R., Thomopoulos, S. I.. 2025-10-27. Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium. https://doi.org/10.1101/2025.10.22.683868

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