Feline leukaemia virus subgrouping using the viral interference assay

Abdillah, D. A.; Hiratsuka, T.; Matsuyama, F.; Hattori, Y.; Soma, T.; Shimoda, T.; Kato, T.; Sakai, H.; Hisasue, M.; Miyake, A.; Nishigaki, K.

doi:10.1101/2025.07.21.665799

bioRxiv · 10.1101/2025.07.21.665799

Feline leukaemia virus subgrouping using the viral interference assay

Abdillah, D. A.·Hiratsuka, T.·Matsuyama, F.·Hattori, Y.·Soma, T.·Shimoda, T.·Kato, T.·Sakai, H.·Hisasue, M.·Miyake, A.·Nishigaki, K.

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Abstract

Feline leukaemia virus subgroup A (FeLV-A) is transmitted among cats, and FeLV subgroups are frequently generated de novo. We investigated the frequency of detection of subgroups using interference assays in 50 cases. FeLV-A infection alone was detected in 38% of cases, whereas co-infection with both FeLV-A and FeLV-B was observed in 62% of cases. No cases of FeLV-B infection alone were observed. Cases of co-infection with FeLV-A and FeLV-B showed a higher prevalence than cases of FeLV-A infection alone. The X region containing FeLV was discovered in two new cases. This study may elucidate the mechanism underlying FeLV-B-induced diseases.

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Abdillah, D. A., Hiratsuka, T., Matsuyama, F., Hattori, Y., Soma, T., Shimoda, T., Kato, T., Sakai, H., Hisasue, M., Miyake, A., Nishigaki, K.. 2025-07-21. Feline leukaemia virus subgrouping using the viral interference assay. https://doi.org/10.1101/2025.07.21.665799

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