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bioRxiv · 10.1101/2025.01.15.633201

In vitro Activity of Citrus IntegroPectin against Lung Cancer Cells

Di Sano, C.·D'Anna, C.·Li Petri, G.·Angellotti, G.·Meneguzzo, F.·Pagliaro, M.·Ciriminna, R.
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Abstract

Citrus IntegroPectin bioconjugates obtained through acoustic cavitation in water of different citrus fruit (lemon, red orange, and sweet orange) processing waste show substantial anticancer activity in vitro against human non- small cell lung cancer cells. Dissolved in aqueous phase at different concentrations, all IntegroPectin phytocomplexes tested affected long-term proliferation and cell migration of adenocarcinoma cells of line A549. Compared to sweet orange, IntegroPectin from lemon and red orange were more effective in reducing colony formation activity. Pointing to significant reduction in cancer cell progression, these results support further investigation of these new low methoxyl pectins rich in citrus flavonoids and RG-I regions for the treatment of lung cancer. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=150 SRC="FIGDIR/small/633201v1_ufig1.gif" ALT="Figure 1"> View larger version (24K): org.highwire.dtl.DTLVardef@166c56eorg.highwire.dtl.DTLVardef@2bd739org.highwire.dtl.DTLVardef@3f0c68org.highwire.dtl.DTLVardef@1479375_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Di Sano, C., D'Anna, C., Li Petri, G., Angellotti, G., Meneguzzo, F., Pagliaro, M., Ciriminna, R.. 2025-01-19. In vitro Activity of Citrus IntegroPectin against Lung Cancer Cells. https://doi.org/10.1101/2025.01.15.633201

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