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bioRxiv · 10.1101/2025.01.09.632085

Ag+-regulated aptamers to thrombin

Alieva, R.·Sokolova, S.·Oleynikov, I.·Novikov, R.·Zatsepin, T.·Aralov, A.·Zavyalova, E.
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Abstract

Nucleic acid aptamers are artificial recognition elements with high potential in biotechnology. Approaches for aptamer affinity optimization and activity regulation are required for aptamer-based nanodevices. Here thrombin aptamer affinity was increased by a single nucleotide modification with 7,8-dihydro-8-oxo-1,N6-ethenoadenine. Whereas a double modification makes the aptamer activity Ag+-dependent.

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Alieva, R., Sokolova, S., Oleynikov, I., Novikov, R., Zatsepin, T., Aralov, A., Zavyalova, E.. 2025-01-09. Ag+-regulated aptamers to thrombin. https://doi.org/10.1101/2025.01.09.632085

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