The role of STN beta oscillations on lower extremity muscle activity in Parkinsonian stepping

Simpson, T. G.; He, S.; Pogosyan, A.; Rodriguez Plazas, F.; Hart, M. G.; Shah, R.; Hasegawa, H.; Wiest, C.; Wehmeyer, L.; Yassine, S.; Guo, X.; Merla, A.; Perera, A.; Raslan, A.; O'Keeffe, A.; Welter, M.-L.; Ashkan, K.; Morgante, F.; Andrade, P.; Visser-Vandewalle, V.; Pereira, E. A.; Tan, H.

doi:10.1101/2025.01.01.631000

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bioRxiv · 10.1101/2025.01.01.631000

The role of STN beta oscillations on lower extremity muscle activity in Parkinsonian stepping

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Abstract

Freezing of gait (FOG) is a devastating symptom of Parkinsons disease (PD) often resulting in disabling falls and loss of independence. It affects half of patients, yet current therapeutic strategies are insufficient, and the underlying neural mechanisms remain poorly understood. This study investigated beta oscillation dynamics in the STN during different locomotor states, while examining the effects of levodopa. In particular, it aimed to identify pathological activity by analysing the relationship between the STN and lower limb muscles during stepping. Local field potentials (LFP) in the STN and muscle activity (EMG) of the gastrocnemius and peroneus longus were recorded in 14 PD patients during standing and stepping, ON and OFF levodopa. Levodopa reduced stepping variability, implying improved stepping abilities. Distinct STN beta patterns were observed between stepping and standing, with lower high-beta and higher low-beta during stepping compared to standing, suggesting a distinct role of these frequency bands in motor control during postural and movement states. Levodopa reduced low-beta but increased high-beta activity, highlighting a potential physiological function of high-beta in the STN during standing and stepping. In addition, step-phase specific effects of levodopa included reduced broad-beta band activity in the STN and lower limb muscles during the late-stance and pushing-off phase of the contralateral leg when ON medication. Further analyses suggest that pathological STN activity amplifies muscle activation around movement initiation, potentially reducing the ability of the patient to move freely. These findings offer insight for developing phase-specific stimulation strategies targeting STN beta oscillations during gait.

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Simpson, T. G., He, S., Pogosyan, A., Rodriguez Plazas, F., Hart, M. G., Shah, R., Hasegawa, H., Wiest, C., Wehmeyer, L., Yassine, S., Guo, X., Merla, A., Perera, A., Raslan, A., O'Keeffe, A., Welter, M.-L., Ashkan, K., Morgante, F., Andrade, P., Visser-Vandewalle, V., Pereira, E. A., Tan, H.. 2025-01-02. The role of STN beta oscillations on lower extremity muscle activity in Parkinsonian stepping. https://doi.org/10.1101/2025.01.01.631000

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