Search bioRxiv⌕ Search

bioRxiv · 10.1101/2024.10.08.617292

Simulations reveal how touchdown kinematic variables affect top sprinting speed: implications for coaching

Abstract

Sprint performance is a priority for coaches and athletes. Several kinematic variables, including horizontal touchdown distance (HTD) and inter-knee touchdown distance (IKTD), are targeted by coaches to increase top sprinting speed. However, the results of past research are conflicting, potentially due to the use of experimental inter-athlete study designs where it is not possible to establish cause-effect relationships. In this study, we used a predictive simulation approach to assess cause-effect relationships between HTD and IKTD and sprinting speed. We scaled a three-dimensional musculoskeletal model to match the anthropometry of an international caliber male sprinter, and generated predictive simulations of a single symmetric step of top-speed sprinting using a direct collocation optimal control framework. We first used our simulation framework to establish the models top speed with minimal constraints on touchdown kinematics (the optimal simulation). Then, in additional simulations we enforced specific HTD or IKTD values ({+/-} 2, 4 and 6 cm compared to optimal). The model achieved a top speed of 11.85 m/s in the optimal simulation. Shortening HTD by 6 cm reduced speed by 7.3%, while lengthening HTD by 6 cm had a smaller impact on speed, with a 1.6% reduction. Speed in the simulation was insensitive to the IKTD changes we tested. The results of our simulations indicate there is an optimal HTD to maximize sprinting speed, providing support for coaches and athletes to adjust this technique variable. Conversely, our results do not provide evidence to support utilizing IKTD as a key technique variable for speed enhancement. We share the simulation framework so researchers can explore the effects of additional modifications on sprinting performance (https://github.com/nicos1993/Pred_Sim_Sprinting).

Source connections

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Haralabidis, N., Eaton, A. J., Delp, S. L., Hicks, J. L.. 2024-10-12. Simulations reveal how touchdown kinematic variables affect top sprinting speed: implications for coaching. https://doi.org/10.1101/2024.10.08.617292

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related preprints

Single-Component Photo-Crosslinked Lipoic Acid Functionalized Mucin Hydrogels: Dynamic Mucus Mimetics for Antiviral Protection

Native mucus protects epithelial surfaces through viscoelastic networks of disulfide-linked mucins. However, commercially available mucins often fail to reconstitute comparable mechanical and barrier properties, while synthetic and hybrid mucus mimetics require polymeric crosslinkers that may alter mucus-like composition. Inspired by the native architecture, we directly functionalized porcine gastric and bovine submaxillary mucins with -lipoic acid to develop a single-component, photo-crosslinkable hydrogels. Upon UV irradiation (365 nm), the modified mucins rapidly form disulfide-crosslinked networks without added photo-initiator/ polymeric crosslinkers, two orders of magnitude faster as compared with PEG-SH approaches. The resulting mucin-lipoic acid (MUC-LA) hydrogels exhibit mucus-relevant properties, including tunable viscoelasticity, redox responsiveness, self-healing, and size-dependent restrictions on nanoparticle transport. In transwell-based infection models, MUC-LA hydrogels (2-3%) mimicking the healthy airway mucus (G' {approx} 10-20 Pa) suppress epithelial infection by SARS-CoV-2 and influenza A virus. Crosslinked MUC-LA provides greater protection against SARS-CoV-2 than the non-crosslinked, whereas both formulations suppress influenza A infection, suggesting distinct contributions from network formation and mucin-associated interactions. These findings establish a dynamic, mucus-mimetic platform integrating rapid photo-gelation, controllable mechanics, selective transport, and antiviral barrier functionality. MUC-LA hydrogels offer opportunities to investigate mucosal transport and host-pathogen interactions, with potential applications in drug delivery, and as biomaterials.

bioengineering↗

A Fibrous Optofluidic Probe for Endovascular Sensing of Blood Oxygenation and Flow Velocity

Local hemodynamic information including blood oxygenation and flow velocity could guide vascular interventions, yet obtaining these parameters in deep, narrow vessels remains challenging. Here, we report a flexible, submillimeter-scale fibrous optofluidic probe for endovascular sensing of blood oxygenation and flow velocity. The probe integrates a polymer optical fiber for light transmission with a microfluidic tube for dye injection, enabling spectroscopic oximetry and fluorescence dilution-based velocimetry through a single device. Via vascular intervention, we demonstrate local hemodynamic sensing in rabbit arteries and angiography-guided deployment in canine carotid arteries. The probe captures local changes in blood oxygenation and flow velocity during vascular occlusion and reperfusion, revealing hemodynamic disturbances that are not reflected in peripheral monitors. These results illustrate the complementary information provided by local oximetry and velocimetry and establish a compact optofluidic platform for quantitative hemodynamic monitoring during vascular interventions.

bioengineering↗

Broad-spectrum in situ genetic reprogramming of native microbiomes

Complex microbial communities are found throughout terrestrial, aquatic, and animal-associated ecosystems. Genetic modification of discrete microbial taxa within native communities represents a powerful tool to study and augment microbiome functions. Herein, we develop Synthetic Phage Assisted Reprogrammable and Targetable Addition (SPARTA) as a one-step strategy for packaging, delivering, and integrating large synthetic DNA into a broad range of native microbiomes. SPARTA leverages a broad-spectrum synthetic phage particle for in situ genome engineering within complex soil, freshwater, and mammalian fecal microbiomes, reprogramming 59 native species across 16 families. By modulating SPARTA components, we further demonstrated tunability of SPARTA towards targeted microbiome population. Additionally, we built a novel companion tool to quantitatively identify engineered taxa, named 16S crRNA-guided inference of bacterial engineering sequencing or ScRibe-seq. The SPARTA-ScRibe-seq pipeline delivered and validated functional synthetic gene clusters in diverse native microbiomes while preserving the original microbial community structure. Together, this novel genome engineering framework constitutes an end-to-end programmable platform for rational and customizable reprogramming of native microbiomes.

bioengineering↗