Attenuated processing of vowels in the left hemisphere predicts speech-in-noise perception deficit in children with autism

Fadeev, K. A.; Romero Reyes, I. V.; Goiaeva, D. E.; Obukhova, T. S.; Ovsiannikova, T. M.; Prokofyev, A. O.; Rytikova, A. M.; Novikov, A. Y.; Kozunov, V. V.; Stroganova, T. A.; Orekhova, E. V.

doi:10.1101/2024.06.24.600191

bioRxiv · 10.1101/2024.06.24.600191

Attenuated processing of vowels in the left hemisphere predicts speech-in-noise perception deficit in children with autism

Fadeev, K. A.·Romero Reyes, I. V.·Goiaeva, D. E.·Obukhova, T. S.·Ovsiannikova, T. M.·Prokofyev, A. O.·Rytikova, A. M.·Novikov, A. Y.·Kozunov, V. V.·Stroganova, T. A.·Orekhova, E. V.

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Abstract

BackgroundDifficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory "object". MethodsWe used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio. ResultsSPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at [~] 150 - 200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise ConclusionsThese results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.

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Fadeev, K. A., Romero Reyes, I. V., Goiaeva, D. E., Obukhova, T. S., Ovsiannikova, T. M., Prokofyev, A. O., Rytikova, A. M., Novikov, A. Y., Kozunov, V. V., Stroganova, T. A., Orekhova, E. V.. 2024-06-28. Attenuated processing of vowels in the left hemisphere predicts speech-in-noise perception deficit in children with autism. https://doi.org/10.1101/2024.06.24.600191

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