Pronouns reactivate conceptual representations in human hippocampal neurons

Abstract

During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words. To minimize repetition and utterance length, languages use pronouns, like the word she, to refer to nouns and phrases that were previously introduced. It has been suggested that language comprehension requires that pronouns activate the same neuronal representations as the nouns themselves. Here, we test this hypothesis by recording from individual neurons in the human hippocampus during a reading task. We found that cells that are selective to a particular noun are later reactivated by pronouns that refer to the cells preferred noun. These results imply that concept cells contribute to a rapid and dynamic semantic memory network which is recruited during language comprehension. This study uniquely demonstrates, at the single-cell level, how memory and language are linked.