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bioRxiv · 10.1101/2023.12.10.570979

GOAT: efficient and robust identification of geneset enrichment

Koopmans, F.
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Abstract

Geneset enrichment analysis is foundational to the interpretation of high throughput biology. We here present GOAT (https://ftwkoopmans.github.io/goat), a parameter-free permutation-based algorithm for geneset enrichment analysis of preranked genelists. Estimated geneset p-values are well calibrated under the null hypothesis and invariant to geneset size. GOAT consistently identifies more Gene Ontology terms in real-world datasets than current methods and is available as an R package and online tool.

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Koopmans, F.. 2023-12-11. GOAT: efficient and robust identification of geneset enrichment. https://doi.org/10.1101/2023.12.10.570979

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