Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling

Coronel-Oliveros, C.; Medel, V.; Orellana, S.; Rodino, J.; Lehue, F.; Cruzat, J.; Tagliazucchi, E.; Brzezicka, A.; Orio, P.; Kowalczyk-Grebska, N.; Ibanez, A.

doi:10.1101/2023.08.21.554072

bioRxiv · 10.1101/2023.08.21.554072

Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling

Coronel-Oliveros, C.·Medel, V.·Orellana, S.·Rodino, J.·Lehue, F.·Cruzat, J.·Tagliazucchi, E.·Brzezicka, A.·Orio, P.·Kowalczyk-Grebska, N.·Ibanez, A.

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Abstract

Video games are a valuable tool for studying the effects of training and neural plasticity on the brain. However, the underlaying mechanisms related to plasticity-induced brain structural changes and their impact in brain dynamics are unknown. Here, we used a semi-empirical whole-brain model to study structural neural plasticity mechanisms linked to video game expertise. We hypothesized that video game expertise is associated with neural plasticity-mediated changes in structural connectivity that manifest at the meso-scale level, resulting in a more segregated functional network topology. To test this hypothesis, we combined structural connectivity data of StarCraft II video game players (VGPs, n = 31) and non-players (NVGPs, n = 31), with generic fMRI data from the Human Connectome Project and computational models, with the aim of generating simulated fMRI recordings. Graph theory analysis on simulated data was performed during both resting-state conditions and external stimulation. VGPs simulated functional connectivity was characterized by a meso-scale integration, with increased local connectivity in frontal, parietal and occipital brain regions. The same analyses at the level of structural connectivity showed no differences between VGPs and NVGPs. Regions that increased their connectivity strength in VGPs are known to be involved in cognitive processes crucial for task performance such as attention, reasoning, and inference. In-silico stimulation suggested that differences in FC between VGPs and NVGPs emerge in noisy contexts, specifically when the noisy level of stimulation is increased. This indicates that the connectomes of VGPs may facilitate the filtering of noise from stimuli. These structural alterations drive the meso-scale functional changes observed in individuals with gaming expertise. Overall, our work sheds light into the mechanisms underlying structural neural plasticity triggered by video game experiences.

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Coronel-Oliveros, C., Medel, V., Orellana, S., Rodino, J., Lehue, F., Cruzat, J., Tagliazucchi, E., Brzezicka, A., Orio, P., Kowalczyk-Grebska, N., Ibanez, A.. 2023-08-22. Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling. https://doi.org/10.1101/2023.08.21.554072

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