High-fat diet-induced obesity increases susceptibility to endogenous and ethyl carbamate-induced somatic mutagenesis

Lichtler, R.; Wilson, M. J.; Wickliffe, J. K.

doi:10.1101/2023.06.14.543760

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bioRxiv · 10.1101/2023.06.14.543760

High-fat diet-induced obesity increases susceptibility to endogenous and ethyl carbamate-induced somatic mutagenesis

Lichtler, R.·Wilson, M. J.·Wickliffe, J. K.

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Abstract

Obesity and dietary fat consumption are associated with increased risk for certain cancers. We conducted a set of experiments designed to investigate both the inherent mutagenicity of high-fat diet (HFD) and the effect of HFD exposure on sensitivity to ethyl carbamate, a known mutagen. Greater body mass in females was associated with higher frequency of Pig-a mutant erythrocytes and HFD-induced obese female mice exhibited increased sensitivity to ethyl carbamate-induced mutagenesis compared to control mice. Together, these findings indicate that HFD exposure induces both endogenously generated changes related to mutagenesis and interacts with the mutagenic effects of ethyl carbamate.

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Lichtler, R., Wilson, M. J., Wickliffe, J. K.. 2023-06-14. High-fat diet-induced obesity increases susceptibility to endogenous and ethyl carbamate-induced somatic mutagenesis. https://doi.org/10.1101/2023.06.14.543760

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