Longitudinal brain structure changes in Parkinson's disease: a replication study

Sokolowski, A.; Bhagwat, N.; Chatelain, Y.; Dugre, M.; Hanganu, A.; Monchi, O.; McPherson, B.; Wang, M.; Poline, J.-B.; Sharp, M.; Glatard, T.

doi:10.1101/2023.04.28.538743

bioRxiv · 10.1101/2023.04.28.538743

Longitudinal brain structure changes in Parkinson's disease: a replication study

Sokolowski, A.·Bhagwat, N.·Chatelain, Y.·Dugre, M.·Hanganu, A.·Monchi, O.·McPherson, B.·Wang, M.·Poline, J.-B.·Sharp, M.·Glatard, T.

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Abstract

ContextAn existing major challenge in Parkinsons disease (PD) research is the identification of biomarkers of disease progression. While Magnetic Resonance Imaging (MRI) is a potential source of PD biomarkers, none of the MRI measures of PD are robust enough to warrant their adoption in clinical research. This study is part of a project that aims to replicate 11 PD studies reviewed in a recent survey (JAMA neurology, 78(10) 2021) to investigate the robustness of PD neuroimaging findings to data and analytical variations. ObjectiveThis study attempts to replicate the results in Hanganu et al. (Brain, 137(4) 2014) using data from the Parkinsons Progression Markers Initiative (PPMI). MethodsUsing 25 PD subjects and 18 healthy controls, we analyzed the rate of change of cortical thickness and of the volume of subcortical structures, and we measured the relationship between MRI structural changes and cognitive decline. We compared our findings to the results in the original study. ResultsSimilarly to the original study, PD patients with mild cognitive impairment (MCI) exhibited increased cortical thinning over time compared to patients without MCI in the right middle temporal gyrus, insula, and precuneus. (2) The rate of cortical thinning in the left inferior temporal and precentral gyri in PD patients correlated with the change in cognitive performance. (3) There were no group differences in the change of subcortical volumes. (4) We did not find a relationship between the change in subcortical volumes and the change in cognitive performance. ConclusionDespite important differences in the dataset used in this replication study, and despite differences in sample size, we were able to partially replicate the original results. We produced a publicly available reproducible notebook allowing researchers to further investigate the reproducibility of the results in Hanganu et al. (2014) when more data becomes available in PPMI.

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Sokolowski, A., Bhagwat, N., Chatelain, Y., Dugre, M., Hanganu, A., Monchi, O., McPherson, B., Wang, M., Poline, J.-B., Sharp, M., Glatard, T.. 2023-04-29. Longitudinal brain structure changes in Parkinson's disease: a replication study. https://doi.org/10.1101/2023.04.28.538743

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