An HBV mRNA vaccine with favorable virological suppression and superior immunity

Lin, A.; Zhao, H.; Yu, Y.; Liu, Z.; Huang, L.; Yang, A.; Jiao, L.; Song, Z.; Wang, Y.; Bao, C.; Yu, R.; Yu, L.; Wang, G.; Wang, D.; Han, Q.; Zhang, L.; Zhang, J.; Yang, Y.

doi:10.1101/2022.11.18.517095

bioRxiv · 10.1101/2022.11.18.517095

An HBV mRNA vaccine with favorable virological suppression and superior immunity

Lin, A.·Zhao, H.·Yu, Y.·Liu, Z.·Huang, L.·Yang, A.·Jiao, L.·Song, Z.·Wang, Y.·Bao, C.·Yu, R.·Yu, L.·Wang, G.·Wang, D.·Han, Q.·Zhang, L.·Zhang, J.·Yang, Y.

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Abstract

BRIEF ABSTRACTHere we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV carrier mouse models generated by viral vector-mediated HBV transfection (pAAV-HBV1.2 and rAAV8-HBV1.3), this vaccine demonstrates sufficient and persistent virological suppression, and robust immunogenicity in terms of induction of strong innate immune activation, high-level virus-specific antibodies, memory B cells and T cells. mRNA platform therefore holds prospects for therapeutic vaccine development to combat CHB.

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Lin, A., Zhao, H., Yu, Y., Liu, Z., Huang, L., Yang, A., Jiao, L., Song, Z., Wang, Y., Bao, C., Yu, R., Yu, L., Wang, G., Wang, D., Han, Q., Zhang, L., Zhang, J., Yang, Y.. 2022-11-19. An HBV mRNA vaccine with favorable virological suppression and superior immunity. https://doi.org/10.1101/2022.11.18.517095

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