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bioRxiv · 10.1101/2022.11.18.517043

SurvBoard: Standardised Benchmarking for Multi-omics Cancer Survival Models

Abstract

Multi-omics data, which include genomic, transcriptomic, epigenetic, and proteomic data, are gaining increasing importance for determining the clinical outcomes of cancer patients. Several recent studies have evaluated various multi-modal integration strategies for cancer survival prediction, highlighting the need for standardizing model performance results. Addressing this issue, we introduce SurvBoard, a benchmark framework that standardizes key experimental design choices. SurvBoard enables comparisons between single-cancer and pan-cancer data models and assesses the benefits of using patient data with missing modalities. We also address common pitfalls in preprocessing and validating multi-omics cancer survival models. We apply SurvBoard to several exemplary use cases, further confirming that statistical models tend to outperform deep learning methods, especially for metrics measuring survival function calibration. Moreover, most models exhibit better performance when trained in a pan-cancer context and can benefit from leveraging samples for which data of some omics modalities are missing. We provide a web service for model evaluation and to make our benchmark results easily accessible and viewable: https://www.survboard.science/. All code is available on GitHub: https://github.com/BoevaLab/survboard/. All benchmark outputs are available on Zenodo: https://zenodo.org/records/11066227. O_TEXTBOXKey MessagesO_LIWe introduce SurvBoard, a comprehensive benchmarking framework for the standardized evaluation of multi-omics cancer survival models. SurvBoard provides an easily accessible platform for the reproducible comparison of models trained on single-cancer and pan-cancer datasets. The platform addresses issues such as the impact of missing modalities and variability in experimental setups. SurvBoard integrates data from four major cancer programs-TCGA, ICGC, TARGET, and METABRIC-to ensure a comprehensive evaluation across diverse types of cancer and research centers. C_LIO_LISurvBoard results confirm that statistical models generally outperform deep learning models in survival function calibration. We also find that pan-cancer training enhances model performance and that models benefit from incorporating data with missing modalities. C_LIO_LISurvBoard includes a web service that allows researchers to submit models for benchmarking and evaluation. A leaderboard is accessible via https://survboard.science/ to promote transparency and the continuous assessment of models performance. C_LI C_TEXTBOX

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BibTeXRIS

Wissel, D., Janakarajan, N., Grover, A., Toniato, E., Martinez, M. R., Boeva, V.. 2022-11-20. SurvBoard: Standardised Benchmarking for Multi-omics Cancer Survival Models. https://doi.org/10.1101/2022.11.18.517043

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