Search bioRxiv⌕ Search

bioRxiv · 10.1101/2022.08.22.504896

Rapid bilevel optimization to concurrently solve musculoskeletal scaling, marker registration, and inverse kinematic problems for human motion reconstruction

Abstract

Creating large-scale public datasets of human motion biomechanics could unlock data-driven breakthroughs in our understanding of human motion, neuromuscular diseases, and assistive devices. However, the manual effort currently required to process motion capture data is costly and limits the collection and sharing of large-scale biomechanical datasets. We present a method to automate and standardize motion capture data processing: bilevel optimization that is able to scale the body segments of a musculoskeletal model, register the locations of optical markers placed on an experimental subject to the markers on a musculoskeletal model, and compute body segment kinematics given trajectories of experimental markers during a motion. The optimization requires less than five minutes of computation to process a subjects motion capture data, compared with about one day of manual work for a human expert. On a sample of 34 trials of experimental data, the root-mean-square marker reconstruction error (RMSE) was 1.38 cm, approximately 40% lower than the 2.58 cm achieved manually by 3 experts. Optimization solutions reconstructed known joint angle trajectories from four diverse motion trials of synthetic data to an average of 0.79 degrees RMSE. We have published an open source cloud service at AddBiomechanics.org to process experimental motion capture data, which is available at no cost and asks that users agree to share processed and de-identified data with the community. Reducing the barriers to processing and sharing high-quality human motion biomechanics data will enable more people to engage in state-of-the-art biomechanical analysis in their work, do so at lower cost, and share larger and more accurate datasets. Author summaryCreating large-scale public datasets of human motion could unlock data-driven breakthroughs in our understanding of neuromuscular diseases, assistive devices, and human motion more broadly. The manual effort currently required to process these motion datasets is costly and limits the collection and sharing of large-scale datasets. Our cloud-based software tool, called AddBiomechanics, uses state-of-the-art optimization techniques to automatically scale the body segments of a musculoskeletal model to match the subject of interest, and then compute body segment kinematics during a motion. The optimization requires less than five minutes of computation to process a subjects motion capture data, compared with about one day of manual work for a human expert. The accuracy of the approach in quantifying the body segment kinematics is as good or better than the results achieved manually by experts. Reducing the barriers to processing and sharing high-quality human motion biomechanics data will enable more people to engage in state-of-the-art biomechanical analysis, do so at lower cost, and share larger and more accurate datasets.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Werling, K., Raitor, M., Stingel, J., Hicks, J. L., Collins, S., Delp, S., Liu, C. K.. 2022-08-23. Rapid bilevel optimization to concurrently solve musculoskeletal scaling, marker registration, and inverse kinematic problems for human motion reconstruction. https://doi.org/10.1101/2022.08.22.504896

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related preprints

Selective activation of estrogen receptors modulates electrical activity and insulin secretion in human EndoC-βH1 cells

Estrogen receptors (ERs), ER and ER{beta} have important roles in the physiology of the endocrine pancreas in animal models, but the effects of ER activation on insulin-secreting human cells are still poorly understood. Here, we investigated the role of ER and ER{beta} as modulators of electrical activity and insulin secretion in the insulin-secreting human cell line EndoC-{beta}H1. Immunocytochemical analysis revealed a widespread cellular distribution of ER, while ER{beta} was predominantly localized outside the nucleus. We observed that both estradiol (E2) and the ER{beta} agonist diarylpropionitrile (DPN) led to a decrease in insulin secretion in the absence of stimulatory glucose concentrations, without affecting insulin content. Patch-clamp experiments revealed that a 48-hour treatment with either the ER agonist PPT or DPN resulted in depolarization of the resting membrane potential, increased action potential firing frequency, and altered the action potential waveform in EndoC-{beta}H1 cells. PPT increased voltage-dependent Ca2+ channel currents, while DPN reduced K+ and Na+ currents. These results suggest that activation of ER and ER{beta} modulates beta-cell electrical activity through distinct pathways involving ion channels. The effects of E2, PPT, and DPN were not caused by altered expression levels of ion channel genes after 48 hours of treatment. This suggests that these receptors act extranuclearly without affecting gene expression. Together, our findings demonstrate that selective activation of ER and ER{beta} modulates beta-cell excitability through distinct electrophysiological mechanisms and that E2 and DPN reduce basal insulin secretion in human EndoC-{beta}H1 cells. These results support ER and ER{beta} as potential targets for modulating human pancreatic beta-cell function.

physiology↗

Body weight modifies the efficacy of lifespan-extending interventions in ad libitum-fed mice

Geroprotective interventions are often assessed by extension of lifespan in ad libitum-fed mice. Increased lifespan could therefore reflect rescue of adverse phenotypes of unhealthy controls. We analysed body weight and survival for 33,780 mice in the Interventions Testing Program (ITP) to test whether treatment effects varied with body weight. In males, each added standard deviation of attained adult weight made treatment 6% more favourable (HR 0.94), more apparent for interventions that lowered body weight (HR 0.90). Median lifespan increase rose from 6.2% in mice in the lightest quartile to 20.2% in the heaviest pre-dosing weight quartile among those experiments, mainly because control survival declined more steeply with weight than that of the intervention group. The effect of body weight was consistent across 13 of 14 compounds and reflected weight attained during adulthood rather than in early life. Weight-dependence of intervention effects was weak in ITP females, possibly because median survival of controls exceeded that of every sampled non-ITP female control group. Amelioration of weight-associated risk is therefore implicated as a major contributor to lifespan increases relative to heavy, short-lived controls. The geroprotective effects of these interventions may thus be less apparent in metabolically healthier mice or humans.

physiology↗

Single-nucleus analysis reveals renal STAT1/CEBPB signaling as a modifiable relay of proinflammatory FGF23 effects in diabetic kidney disease

Background Circulating fibroblast growth factor 23 (FGF23) rises dramatically in chronic kidney disease, particularly in diabetic kidney disease (DKD). At high concentrations, and with declining Klotho, FGF23 has been linked to renal inflammation. The cell types and transcriptional programs mediating these off-target actions remain undefined. We asked whether the diseased kidney responds to FGF23 differently from the healthy kidney, and whether any disease-specific response could be targeted. Methods Male and female DBA/2J mice received streptozotocin or vehicle to induce DKD. On day 56, mice received a single dose intravenous injection of FGF23 (0.3 g) or vehicle, with tissue collected 1 h later for single-nucleus RNA sequencing, differential expression and regulon (inferred transcription factor activity) analysis. Candidate pathways were tested in precision-cut kidney slices using the CEBPB inhibitor ST-101. Results Streptozotocin-treated male mice developed early DKD with a 6-fold increase in urinary albumin/creatinine ratio and 50% higher blood urea nitrogen with preserved glomerular filtration rate. All major renal cell types were annotated. Canonical FGF23 signaling was intact in disease, with segment-specific target induction conserved in both conditions (e.g. Cyp24a1 in PT-S1 and DCT1). Superimposed on this were disease-restricted responses, including Wsb1 in DCT1 and Pdk4 in PT-S2, PST, DCT1 and DCT2. Regulon analysis revealed DKD-specific induction of CEBPB regulon activity by FGF23 across all analyzed tubular segments, and of STAT1 in several segments. Pre-treatment with a CEBPB inhibitor suppressed CEBPB activity, downstream NF-KB and pro-inflammatory gene sets, and immune-like cell abundance in diseased slices. Conclusion In the diabetic kidney, FGF23 engages a STAT1-CEBPB-NF-{kappa}B axis absent from healthy kidney and extending beyond its canonical Klotho-dependent target segments, identifying CEBPB as a potential treatment target for FGF23's pathological inflammatory actions.

physiology↗