Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.

Taglauer, E.; Dhole, Y.; Boateng, J.; Snyder-Cappione, J. E.; Parker, S. E.; Clarke, K.; Juttukonda, L.; Devera, J.; Hunnewell, J.; Barnett, E.; Jia, H.; Yarrington, C.; Sabharwal, V.; Wachman, E.

doi:10.1101/2021.12.26.472655

bioRxiv · 10.1101/2021.12.26.472655

Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.

Taglauer, E.·Dhole, Y.·Boateng, J.·Snyder-Cappione, J. E.·Parker, S. E.·Clarke, K.·Juttukonda, L.·Devera, J.·Hunnewell, J.·Barnett, E.·Jia, H.·Yarrington, C.·Sabharwal, V.·Wachman, E.

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Abstract

ObjectiveSARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy. Study DesignSerum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay. ResultsIn comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p<0.05) and IL-8 uniquely elevated in COVID infant samples (p<0.05). Significant elevations in IL-6, IP-10 and IL-8 were found among both early (1st/2nd Trimester) and late (3rd Trimester) maternal SARS-CoV-2 infections. ConclusionsMaternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health.

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Taglauer, E., Dhole, Y., Boateng, J., Snyder-Cappione, J. E., Parker, S. E., Clarke, K., Juttukonda, L., Devera, J., Hunnewell, J., Barnett, E., Jia, H., Yarrington, C., Sabharwal, V., Wachman, E.. 2021-12-28. Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.. https://doi.org/10.1101/2021.12.26.472655

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