Low dose inocula of SARS-CoV-2 B.1.1.7 variant initiate more robust infections in the upper respiratory tract of hamsters than earlier D614G variants

Mok, B. W.-Y.; Liu, H.; Lau, S.-Y.; Deng, S. D.; Liu, S.; Tam, R. C.-Y.; Ng, T. T.-L.; Leung, J. S.-L.; Wang, P.; To, K. K.-W.; Chan, J. F.-W.; Chan, K.-H.; Yuen, K.-Y.; Siu, G. K.-H.; Chen, H.

doi:10.1101/2021.04.19.440414

bioRxiv · 10.1101/2021.04.19.440414

Low dose inocula of SARS-CoV-2 B.1.1.7 variant initiate more robust infections in the upper respiratory tract of hamsters than earlier D614G variants

Mok, B. W.-Y.·Liu, H.·Lau, S.-Y.·Deng, S. D.·Liu, S.·Tam, R. C.-Y.·Ng, T. T.-L.·Leung, J. S.-L.·Wang, P.·To, K. K.-W.·Chan, J. F.-W.·Chan, K.-H.·Yuen, K.-Y.·Siu, G. K.-H.·Chen, H.

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Abstract

There is a lack of experimental evidence to explain how the B.1.1.7 variant spreads more quickly than pre-existing variants in humans. We found that B.1.1.7 displays increased competitive fitness over earlier D614G lineages in an in-vitro system. Furthermore,, we demonstrated that B.1.1.7 variant is able to replicate and shed more efficiently in the nasal cavity than other variants with lower dose and shorter duration of exposure.

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Mok, B. W.-Y., Liu, H., Lau, S.-Y., Deng, S. D., Liu, S., Tam, R. C.-Y., Ng, T. T.-L., Leung, J. S.-L., Wang, P., To, K. K.-W., Chan, J. F.-W., Chan, K.-H., Yuen, K.-Y., Siu, G. K.-H., Chen, H.. 2021-04-19. Low dose inocula of SARS-CoV-2 B.1.1.7 variant initiate more robust infections in the upper respiratory tract of hamsters than earlier D614G variants. https://doi.org/10.1101/2021.04.19.440414

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