Post-encoding reactivation promotes one-shot learning of episodes in humans

Abstract

Prior animal and human work have shown that post-encoding reinstatement plays an important role in organizing the temporal sequence of unfolding episodes in memory. Here, we investigated whether post-encoding reinstatement serves to promote the encoding of one-shot episodic learning beyond the temporal structure in humans. In experiment 1, participants encoded sequences of pictures depicting unique and meaningful episodic-like events. We used representational similarity analysis on scalp electroencephalography recordings during encoding and found evidence of rapid picture elicited EEG patterns reinstatement at episodic offset (around 500ms post-episode). Memory reinstatement was not observed between successive elements within an episode and the degree of memory reinstatement at episodic offset predicted later recall for that episode. In experiment 2, participants encoded a shuffled version of the picture sequences from experiment 1, rendering each episode meaningless to the participant but temporally structured as in experiment 1, and we found no evidence of memory reinstatement at episodic offset. These results suggest that post-encoding memory reinstatement is akin to the rapid formation of unique and meaningful episodes that unfold over time.