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bioRxiv · 10.1101/2020.07.15.204305

Small molecule resensitizes Salmonella to itaconate and decreases bacterial proliferation in macrophages

Duncan, D.·Chang, J. H.·Artyomov, M. N.·Auclair, K.
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Abstract

Antimicrobial resistance is a global health crisis offering little reprieve. The situation urgently calls for new drug targets and therapies for infections. We have previously suggested a different approach to treat infections, termed bacterio-modulation, in which a compound modulates the bacterial response to the host immune defense. Herein we show that monocytes infected with Salmonella enterica spp. Typhimurium can be cured using non-antimicrobial compounds that resensitize the bacterium to itaconate, a macrophage-derived antimicrobial metabolite. We propose that this represents a novel strategy to treat infections.

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Duncan, D., Chang, J. H., Artyomov, M. N., Auclair, K.. 2020-07-15. Small molecule resensitizes Salmonella to itaconate and decreases bacterial proliferation in macrophages. https://doi.org/10.1101/2020.07.15.204305

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