Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections

Benard, A.; Jacobsen, A.; Brunner, M.; Krautz, C.; Klosch, B.; Swierzy, I.; Naschberger, E.; Birkholz, T.; Castellanos, I.; Trufa, D.; Sirbu, H.; Vetter, M.; Kremer, A. E.; Hildner, K.; Hecker, A.; Edinger, F.; Tenbusch, M.; Richter, E.; Streeck, H.; Berger, M. M.; Brenner, T.; Weigand, M. A.; Swirski, F. K.; Schett, G.; Grutzmann, R.; Weber, G. F.

doi:10.1101/2020.07.02.184093

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bioRxiv · 10.1101/2020.07.02.184093

Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. Here, we report that low plasma interleukin-3 (IL-3) levels were associated with increased severity and mortality during SARS-CoV-2 infections. IL-3 promoted the recruitment of antiviral circulating plasmacytoid dendritic cells (pDCs) into the airways by stimulating CXCL12 secretion from pulmonary CD123+ epithelial cells. This study identifies IL-3 as a predictive disease marker and potential therapeutic target for SARS-CoV-2 infections.Competing Interest StatementThe authors have declared no competing interest.View Full Text

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Benard, A., Jacobsen, A., Brunner, M., Krautz, C., Klosch, B., Swierzy, I., Naschberger, E., Birkholz, T., Castellanos, I., Trufa, D., Sirbu, H., Vetter, M., Kremer, A. E., Hildner, K., Hecker, A., Edinger, F., Tenbusch, M., Richter, E., Streeck, H., Berger, M. M., Brenner, T., Weigand, M. A., Swirski, F. K., Schett, G., Grutzmann, R., Weber, G. F.. 2020-07-02. Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections. https://doi.org/10.1101/2020.07.02.184093

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