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bioRxiv · 10.1101/2020.04.20.049791

A flexible target-specific anti-infection therapeutic platform that can be applied to different microbial species

Mitsunaga, M.·Ito, K.·Nishimura, T.·Miyata, H.·Mizunoe, Y.·Kobayashi, H.·Iwase, T.
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Abstract

The emergence of new microbial pathogens, including drug-resistant strains, complicates treatment, thereby threatening global health. We demonstrated a photoimmuno-antimicrobial strategy (PIAS) that eliminated antibody-targets using a photo-activated anti-pathogen antibody generating mechanical stress that damaged the targets binding sites. PIAS is effective against many pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), the fungal pathogen Candida albicans, and viral particles irrespective of their species or drug-resistance status. Animal experiments demonstrated that PIAS saved mice from fatal infections; microbiome and histochemical analyses indicated no apparent effect on normal host microflora and tissues in PIAS-treated mice. Resistance to PIAS was not observed during the eight years of this study. As a new type of anti-infection therapy, PIAS may contribute to advances in anti-infection strategies.

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Mitsunaga, M., Ito, K., Nishimura, T., Miyata, H., Mizunoe, Y., Kobayashi, H., Iwase, T.. 2020-04-23. A flexible target-specific anti-infection therapeutic platform that can be applied to different microbial species. https://doi.org/10.1101/2020.04.20.049791

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