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bioRxiv · 10.1101/2019.12.13.874495

Spatial mapping of cell types by integration of transcriptomics data

Andersson, A.·Bergenstråhle, J.·Asp, M.·Navarro, J. F.·Bergenstrahle, L.·Jurek, A.·Lundeberg, J.
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Abstract

Spatial transcriptomics and single cell RNA-sequencing offer complementary insights into the transcriptional expression landscape. We here present a probabilistic method that integrates data from both techniques, leveraging their respective strengths in such a way that we are able to spatially map cell types to a tissue. The method is applied to several different types of tissue where the spatial cell type topographies are successfully delineated.

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Andersson, A., Bergenstråhle, J., Asp, M., Navarro, J. F., Bergenstrahle, L., Jurek, A., Lundeberg, J.. 2019-12-13. Spatial mapping of cell types by integration of transcriptomics data. https://doi.org/10.1101/2019.12.13.874495

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