A Core Speech Circuit Between Primary Motor, Somatosensory, And Auditory Cortex: Evidence From Connectivity And Genetic Descriptions

Abstract

What adaptations allow humans to produce and perceive speech so effortlessly? We show that speech is supported by a largely undocumented core of structural and functional connectivity between the central sulcus (CS or primary motor and somatosensory cortex) and the transverse temporal gyrus (TTG or primary auditory cortex). Anatomically, we show that CS and TTG cortical thickness covary across individuals and that they are connected by white matter tracts. Neuroimaging network analyses confirm the functional relevance and specificity of these structural relationships. Specifically, the CS and TTG are functionally connected at rest, during natural audiovisual speech perception, and are coactive over a large variety of linguistic stimuli and tasks. Importantly, across structural and functional analyses, connectivity of regions immediately adjacent to the TTG are with premotor and prefrontal regions rather than the CS. Finally, we show that this structural/functional CS-TTG relationship is mediated by a constellation of genes associated with vocal learning and disorders of efference copy. We propose that this core circuit constitutes an interface for rapidly exchanging articulatory and acoustic information and discuss implications for current models of speech.