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bioRxiv · 10.1101/109298

Can the location of a trophectoderm biopsy contribute to human blastocyst development ?

Takano, T.·Funabiki, M.·Taguchi, S.·Saji, F.·Amano, N.·Young, K. L.·Nakamura, Y.
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Abstract

The influence of the location of a trophectoderm biopsy in human blastocysts on the development of those blastocysts has not yet been investigated. In our prospective study (n=92), our multivariate logistic regression analysis indicated that blastocoel development was influenced by the location of the trophectoderm biopsy (p=0.049) and by the type of human blastocyst used (fresh or thawed) (p=0.037), regardless of the patients age (p=0.507) and the number of days for the human blastocyst in the pretrophectoderm biopsy (p=0.239). Therefore, when a trophectoderm biopsy is close to the inner cell mass (ICM) in human blastocysts, it improves the progress of blastocoel development.\n\nClinical evidence suggests that the progress of blastocoel development is a predictor of clinical outcomes after single blastocyst transfer. Therefore, when the trophectoderm biopsy is done from near the ICM, improvement of clinical outcomes after single blastocyst transfer may be expected.

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Takano, T., Funabiki, M., Taguchi, S., Saji, F., Amano, N., Young, K. L., Nakamura, Y.. 2017-02-20. Can the location of a trophectoderm biopsy contribute to human blastocyst development ?. https://doi.org/10.1101/109298

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