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bioRxiv2026

Unmasking genetic load: Genomic inbreeding drives growth depression in captive critically endangered Chinese Bahaba (Bahaba taipingensis)

Chinese bahaba (Bahaba taipingensis) is a critically endangered marine fish that has been commercially extinct in the wild. Conservation-oriented captive breeding has become an effective strategy for rescuing such endangered species, but concerns about inbreeding depression often remain. Here, after merely two generations of closed breeding from 18 wild founders, Chinese bahaba exhibited severe growth depression, with body length and weight diverging by more than three-fold. To further investigate the early genomic consequences of captive breeding, we analyzed whole-genome sequences from 348 F2 individuals together with 19 wild individuals from the same marine region. While genome-wide genetic diversity was overall preserved, closed breeding rapidly partitioned the F2 population into eight distinct genetic lineages. A significant elevation in genomic inbreeding was observed to facilitate the homozygous exposure of recessive deleterious mutations, which was strongly correlated with growth decline. An integrative framework combining GWAS, gene-level burden test, and ROH hotspots was applied to dissect the genetic architecture underlying growth decline, which converged predominantly on skeletal scaffolding and immune regulation. This was evidenced by candidate genes related to skeleton development and homeostasis (e.g. fam20b, c-fos, trpv5, and il23r), the GH/IGF axis (e.g. socs1a), and immune/inflammatory pathways (e.g. il23r, nlrp7, cd163, il12rb2), as well as calcium ion transport pathway. Together, our findings provide novel insights into the genomic consequences and genetic architecture of growth decline under captive conditions in Chinese bahaba, and offer critical guidance for genetic management in captive conservation programs of endangered species.

genetics↗

bioRxiv2026

BATOseq-PE: A public batoid DNA library with the first molecular insights into the cryptic diversity, genetic health, and management of Peruvian marine rays

Batoids (rays, skates, and relatives) are among the most threatened cartilaginous fishes globally, yet the molecular diversity of Peruvian taxa remains poorly evaluated. Furthermore, regional barcode sequences for high-conservation-priority taxa, such as sawfish, manta, and devil rays, are often restricted to private records, hindering essential phylogeographic and population structure assessments. To bridge this gap, we developed BATOseq-PE, the first public genetic reference library for Peruvian marine batoids, covering 14 species sequenced in vitro from local specimens, complemented by a novel in silico assembled mitogenome for Notoraja martinezi. This open-access repository contributes 73 novel COI barcodes, providing robust taxonomic resolution across 15 molecular operational taxonomic units (MOTUs) and Barcode Index Numbers (BINs). Notably, we provide the first Peruvian public records for high-priority species such as Mobula munkiana, Mobula thurstoni, Myliobatis peruviana, Rostroraja velezi, and the first global public barcodes for N. martinezi and Zapteryx xyster. By coupling BATOseq-PE with global datasets, we conducted the first multi-taxa screening for delimitation and phylogeographic assessments on Peruvian batoids, revealing a cryptic lineage within R. velezi and genetic connectivity patterns suggesting female philopatry in Mobula mobular. Finally, by integrating nucleotide diversity into a Genetic Diversity Risk Indicator (GDRI) alongside ecological and fishery data, we identified an alarming trend where heavy fishing pressure overlaps with extinction risk and depleted genetic diversity, allowing us to suggest data-driven, tailored management strategies. BATOseq-PE represents a valuable resource to accelerate taxonomic and population assessments, ultimately fostering ray conservation through the integration of genetic frameworks into fishery management.

genetics↗

bioRxiv2026

Genetic diversity of endangered Acropora spp. corals in Bonaire: implications for restoration and gene banking

Species restoration is a valuable tool to combat biodiversity loss. However, maintaining genetic diversity in species restoration is challenging, particularly for species that can reproduce asexually, such as plants and corals, because a seemingly diverse collection of individuals could be composed of many clones of a few genotypes. Caribbean elkhorn and staghorn corals (Acropora palmata, A. cervicornis) are critically endangered reef-building corals that are a major target for restoration. To better understand the genetic diversity of an Acropora spp. restoration program and interpret local population genetic structure, we conducted microsatellite genotyping on the gene banks of 35 A. palmata lineages and 25 A. cervicornis lineages maintained by Reef Renewal Foundation Bonaire (RRFB) in the Caribbean Netherlands. We found that RRFB had high genotypic richness for A. palmata (0.971) and A. cervicornis (1.0) and estimated that they captured 88.9% and 74.7% of Bonaires microsatellite asymptotic allelic diversity, respectively. Compared to populations of Acropora spp. studied in other locations across the Caribbean, A. palmata in Bonaire had relatively low expected heterozygosity, while A. cervicornis was greater than approximately half of other populations. Across Bonaire and for both coral species, we did not find evidence for genetic structuring among spatially separated subpopulations, indicating that both species are likely well-connected around the island. Together, these results demonstrate the effectiveness of RRFBs strategies to capture high genetic diversity and can be used to inform future initiatives on coral sexual breeding and assisted gene flow beyond Bonaire.

genetics↗

bioRxiv2026

GxE and changes to the genetic architecture of flowering time in an overwintering environment

Characterizing how the expression of genetic variation changes across environments is essential for understanding evolution in complex environments, the evolution of phenotypic plasticity, and the genetic architecture of adaptation. We investigated how the phenotypic distribution, large-effect loci, and polygenetic architecture of flowering time in Arabidopsis thaliana changes when grown in an ecologically realistic environment compared to standard chamber conditions. We grew 479 A. thaliana accessions in an overwintering common garden that have previously been phenotyped in growth chambers by the 1001 Genomes Project (2016). Our findings suggest there is extensive GxE for flowering time between the overwintering common garden and the growth chamber environments. None of the large effect loci that we identified using a multivariate Genome Wide Association Study (GWAS) were shared across growth conditions. We find evidence of allelic differential sensitivity, conditional neutrality, and antagonistic pleiotropy contributing to GxE for flowering time between growth conditions. Our results also suggest that the effects of genetic variation across multiple flowering time regulatory pathways is revealed when grown in a more ecologically realistic environment. The effect sizes for the most significant 1% of SNPs are moderately correlated between the outdoor and growth chamber conditions which indicates a partially shared genetic basis. Overall, our findings highlight how making inferences about the genetic basis and evolution of complex traits may be dependent on conducting experiments in ecologically realistic environments.

genetics↗

bioRxiv2026

LRCP: identifying functionally related SNPs and genes from phenome-wide genetic-effect correlations using GWAS summary statistics

Genetic correlation describes which traits share genetic causes. The transposed question, which variants act alike across the phenome, has no comparable estimator, although it points directly to shared genes, pathways and regulators. Correlations of GWAS Z scores between variants across many traits are easy to compute, but they are confounded by linkage disequilibrium (LD) and, for any pair of variants, by sample overlap and genetic correlation among the GWAS. We show that in 452 Pan-UK Biobank GWAS the effective number of independent traits is only 58, and that naive tests reject 51-70% of null pairs of distal variants. We introduce LRCP (likelihood and regression on cross-products of Z scores), which estimates the phenome-wide genetic-effect correlation{rho} between SNPs by regressing Z-score cross-products on LD cross components, using per-SNP heritability enrichment from the companion method LRCQ and LDSC-derived plug-ins. For variants in different LD blocks the estimator has a closed form, and its standard errors account exactly for the dependence among GWAS. In simulations LRCP is unbiased (absolute bias at most 0.03), its 95% intervals cover 93-98%, and its type-I error is 5.0-5.7%, whereas naive correlations are attenuated by 41-64% and reject up to 51% of null pairs. In Pan-UK Biobank, LRCP recovers the expected signs among PCSK9, LDLR and APOB variants and estimates{rho} = 0.90 between the TP53 polyadenylation variant rs78378222 and MDM2 rs3730556, whose Z scores correlate at r = 0.67 across traits (conditional bootstrap P = 0.015), although this correlation lies along a shared body-size and red-cell trait axis. Single variant pairs are near the resolution of current biobanks, with precision limited by the number of genetically distinct traits. Genome-wide, among 7,793 enriched LD clumps (30.2 million distal pairs), a conditional test finds 17 pairs at FDR 5%, where naive correlation flags 23 million. Simulating the whole screen under the null shows that this test is conservative and that the 113 strongest links (P < 10-5) lie far beyond the null, which yields 0.025 such pairs per screen. Linked genes share Reactome pathways 4.9 times more often than random pairs of enriched loci. The top pairs form 19 modules, the largest of which match known biology: myeloid differentiation (IRF8, CEBPE, IKZF1), LDL and HDL metabolism, iron homeostasis (TMPRSS6, TFRC), the red-cell membrane (SPTA1, ANK1) and type-2 immunity (TSLP, IL13). LRCP turns phenome-wide summary statistics into a map of functionally related variants and genes.

genetics↗

bioRxiv2014

The evolution of genetic diversity in changing environments

The production and maintenance of genetic and phenotypic diversity under temporally fluctuating selection and the signatures of environmental and selective volatility in the patterns of genetic and phenotypic variation have been important areas of focus in population genetics. On one hand, stretches of constant selection pull the genetic makeup of populations towards local fitness optima. On the other, in order to cope with changes in the selection regime, populations may evolve mechanisms that create a diversity of genotypes. By tuning the rates at which variability is produced, such as the rates of recombination, mutation or migration, populations may increase their long-term adaptability. Here we use theoretical models to gain insight into how the rates of these three evolutionary forces are shaped by fluctuating selection. We compare and contrast the evolution of recombination, mutation and migration under similar patterns of environmental change and show that these three sources of phenotypic variation are surprisingly similar in their response to changing selection. We show that knowing the shape, size, variance and asymmetry of environmental runs is essential for accurate prediction of genetic evolutionary dynamics.

Evolutionary Biology↗

bioRxiv2014

THE GENETIC LANDSCAPE OF TRANSCRIPTIONAL NETWORKS IN A COMBINED HAPLOID/DIPLOID PLANT SYSTEM

Heritable variation in gene expression is a source of evolutionary change and our understanding of the genetic basis of expression variation remains incomplete. Here, we dissected the genetic basis of transcriptional variation in a wild, outbreeding gymnosperm (Picea glauca) according to linked and unlinked genetic variants, their allele-specific (cis) and allele non-specific (trans) effects, and their phenotypic additivity. We used a novel plant system that is based on the analysis of segregating alleles of a single self-fertilized plant in haploid and diploid seed tissues. We measured transcript abundance and identified transcribed SNPs in 66 seeds with RNA-seq. Linked and unlinked genetic effects that influenced expression levels were abundant in the haploid megagametophyte tissue, influencing 48% and 38% of analyzed genes, respectively. Analysis of these effects in diploid embryos revealed that while distant effects were acting in trans consistent with their hypothesized diffusible nature, local effects were associated with a complex mix of cis, trans and compensatory effects. Most cis effects were additive irrespective of their effect sizes, consistent with a hypothesis that they represent rate-limiting factors in transcript accumulation. We show that trans effects fulfilled a key prediction of Wright s physiological theory, in which variants with small effects tend to be additive and those with large effects tend to be dominant/recessive. Our haploid/diploid approach allows a comprehensive genetic dissection of expression variation and can be applied to a large number of wild plant species.

Genomics↗

bioRxiv2015

Natural Selection Shapes the Mosaic Ancestry of the Drosophila Genetic Reference Panel and the D. melanogaster Reference Genome

North American populations of Drosophila melanogaster are thought to derive from both European and African source populations, but despite their importance for genetic research, patterns of admixture along their genomes are essentially undocumented. Here, I infer geographic ancestry along genomes of the Drosophila Genetic Reference Panel (DGRP) and the D. melanogaster reference genome. Overall, the proportion of African ancestry was estimated to be 20% for the DGRP and 9% for the reference genome. Based on the size of admixture tracts and the approximate timing of admixture, I estimate that the DGRP population underwent roughly 13.9 generations per year. Notably, ancestry levels varied strikingly among genomic regions, with significantly less African introgression on the X chromosome, in regions of high recombination, and at genes involved in specific processes such as circadian rhythm. An important role for natural selection during the admixture process was further supported by a genome-wide signal of ancestry disequilibrium, in that many between-chromosome pairs of loci showed a deficiency of Africa-Europe allele combinations. These results support the hypothesis that admixture between partially genetically isolated Drosophila populations led to natural selection against incompatible genetic variants, and that this process is ongoing. The ancestry blocks inferred here may be relevant for the performance of reference alignment in this species, and may bolster the design and interpretation of many population genetic and association mapping studies.

Evolutionary Biology↗

bioRxiv2015

Is there such a thing as Landscape Genetics?

For a scientific discipline to be interdisciplinary it must satisfy two conditions; it must consist of contributions from at least two existing disciplines and it must be able to provide insights, through this interaction, that neither progenitor discipline could address. In this paper, I examine the complete body of peer-reviewed literature self-identified as landscape genetics using the statistical approaches of text mining and natural language processing. The goal here is to quantify the kinds of questions being addressed in landscape genetic studies, the ways in which questions are evaluated mechanistically, and how they are differentiated from the progenitor disciplines of landscape ecology and population genetics. I then circumscribe the main factions within published landscape genetic papers examining the extent to which emergent questions are being addressed and highlighting a deep bifurcation between existing individual- and population-based approaches. I close by providing some suggestions on where theoretical and analytical work is needed if landscape genetics is to serve as a real bridge connecting evolution and ecology sensu lato.

Evolutionary Biology↗

bioRxiv2015

Application of a dense genetic map for assessment of genomic responses to selection and inbreeding in Heliothis virescens.

Adaptation of pest species to laboratory conditions and selection for resistance to toxins in the laboratory are expected to cause inbreeding and genetic bottlenecks that reduce genetic variation. Heliothis virescens, a major cotton pest, has been colonized in the laboratory many times, and a few laboratory colonies have been selected for Bt resistance. We developed 350 bp Double-Digest Restriction-site Associated DNA-sequencing (ddRAD-seq) molecular markers to examine and compare changes in genetic variation associated with laboratory adaptation, artificial selection, and inbreeding in this non-model insect species. We found that allelic and nucleotide diversity declined dramatically in laboratory-reared H. virescens as compared with field-collected populations. The declines were primarily due to the loss of low frequency alleles present in field-collected H. virescens. A further, albeit modest decline in genetic diversity was observed in a Bt-selected population. The greatest decline was seen in H. virescens that were sib-mated for 10 generations, where more than 80% of loci were fixed for a single allele. To determine which regions of the genome were resistant to fixation in our sib-mated line, we generated a dense intraspecific linkage map containing 3 PCR-based, and 659 ddRAD-seq markers. Markers that retained polymorphism were observed in small clusters spread over multiple linkage groups, but this clustering was not statistically significant. Here, we confirmed and extended the general expectations for reduced genetic diversity in laboratory colonies, provided tools for further genomic analyses, and produced highly homozygous genomic DNA for future whole genome sequencing of H. virescens.

Genomics↗

bioRxiv2015

Quantitative Genetics Meets Integral Projection Models: Unification of Widely Used Methods from Ecology and Evolution

O_LIMicro-evolutionary predictions are complicated by ecological feedbacks like density dependence, while ecological predictions can be complicated by evolutionary change. A widely used approach in micro-evolution, quantitative genetics, struggles to incorporate ecological processes into predictive models, while structured population modelling, a tool widely used in ecology, rarely incorporates evolution explicitly.\nC_LIO_LIIn this paper we develop a flexible, general framework that links quantitative genetics and structured population models. We use the quantitative genetic approach to write down the phenotype as an additive map. We then construct integral projection models for each component of the phenotype. The dynamics of the distribution of the phenotype are generated by combining distributions of each of its components. Population projection models can be formulated on per generation or on shorter time steps.\nC_LIO_LIWe introduce the framework before developing example models with parameters chosen to exhibit specific dynamics. These models reveal (i) how evolution of a phenotype can cause populations to move from one dynamical regime to another (e.g. from stationarity to cycles), (ii) how additive genetic variances and covariances (the G matrix) are expected to evolve over multiple generations, (iii) how changing heritability with age can maintain additive genetic variation in the face of selection and (iii) life history, population dynamics, phenotypic characters and parameters in ecological models will change as adaptation occurs.\nC_LIO_LIOur approach unifies population ecology and evolutionary biology providing a framework allowing a very wide range of questions to be addressed. The next step is to apply the approach to a variety of laboratory and field systems. Once this is done we will have a much deeper understanding of eco-evolutionary dynamics and feedbacks.\nC_LI

Evolutionary Biology↗

bioRxiv2016

A genetic test for differential causative pathology in disease subgroups

Many common diseases show wide phenotypic variation. We present a statistical method for determining whether phenotypically defined subgroups of disease cases represent different genetic architectures, in which disease-associated variants have different effect sizes in the two subgroups. Our method models the genome-wide distributions of genetic association statistics with mixture Gaussians. We apply a global test without requiring explicit identification of disease-associated variants, thus maximising power in comparison to a standard variant by variant subgroup analysis. Where evidence for genetic subgrouping is found, we present methods for post-hoc identification of the contributing genetic variants.\n\nWe demonstrate the method on a range of simulated and test datasets where expected results are already known. We investigate subgroups of type 1 diabetes (T1D) cases defined by autoantibody positivity, establishing evidence for differential genetic architecture with thyroid peroxidase antibody positivity, driven generally by variants in known T1D associated regions.

Genomics↗

bioRxiv2016

The genetic architecture of local adaptation II: The QTL landscape of water-use efficiency for foxtail pine (Pinus balfouriana Grev. & Balf.)

Water availability is an important driver of the geographic distribution of many plant species, although its importance relative to other climatic variables varies across climate regimes and species. A common indirect measure of water-use efficiency (WUE) is the ratio of carbon isotopes ({delta}13C) fixed during photosynthesis, especially when analyzed in conjunction with a measure of leaf-level resource utilization ({delta}15N). Here, we test two hypotheses about the genetic architecture of WUE for foxtail pine (Pinus balfouriana Grev. & Balf.) using a novel mixture of double digest restriction site associated DNA sequencing, species distribution modeling, and quantitative genetics. First, we test the hypothesis that water availability is an important determinant of the geographical range of foxtail pine. Second, we test the hypothesis that variation in {delta}13C and {delta}15N is genetically based, differentiated between regional populations, and has genetic architectures that include loci of large effect. We show that precipitation-related variables structured the geographical range of foxtail pine, climate-based niches differed between regional populations, and {delta}13C and {delta}15N were heritable with moderate signals of differentiation between regional populations. A set of large-effect QTLs (n = 11 for {delta}13C; n = 10 for {delta}15N) underlying {delta}13C and {delta}15N variation, with little to no evidence of pleiotropy, was discovered using multiple-marker, half-sibling regression models. Our results represent a first approximation to the genetic architecture of these phenotypic traits, including documentation of several patterns consistent with {delta}13C being a fitness-related trait affected by natural selection.

Evolutionary Biology↗

bioRxiv2016

Mixing of Porpoise Ecotypes in South Western UK Waters Revealed by Genetic Profiling

Contact zones between marine ecotypes are of interest for understanding how key pelagic predators may react to climate change. We analysed the fine scale genetic structure and morphological variation in harbour porpoises around the UK, at the proposed northern limit of a contact zone between southern and northern ecotypes in the Bay of Biscay. Using a sample of 591 stranded animals spanning a decade and microsatellite profiling at 9 loci, clustering and spatial analyses revealed that animals stranded around UK are composed of mixed genetic ancestries from two genetic pools. Porpoises from SW England displayed a distinct genetic ancestry, had larger body-sizes and inhabit an environment differentiated from other UK costal areas. Genetic ancestry blends from one group to the other along a SW-NE axis along the UK coastline, and showed a significant association with body size, consistent with morphological differences between the two ecotypes and their mixing around the SW coast. We also found significant isolation-by-distance among juveniles, suggesting that stranded juveniles display reduced intergenerational dispersal, while adults show larger variance. The fine scale structure of this admixture zone raises the question of how it will respond to future climate change and provides a reference point for further study.

Evolutionary Biology↗

bioRxiv2016

Levels and patterns of genetic diversity differ between two closely related endemic Arabidopsis species

Theory predicts that a small effective population size leads to slower accumulation of mutations, increased levels of genetic drift and reduction in the efficiency of natural selection. Therefore endemic species should harbor low levels of genetic diversity and exhibit a reduced ability of adaptation to environmental changes. Arabidopsis pedemontana and Arabidopsis cebennensis, two endemic species from Italy and France respectively, provide an excellent model to study the adaptive potential of species with small distribution ranges. To evaluate the genome-wide levels and patterns of genetic variation, effective population size and demographic history of both species, we genotyped 53 A. pedemontana and 28 A. cebennensis individuals across the entire species ranges with Genotyping-by-Sequencing. SNPs data confirmed a low genetic diversity for A. pedemontana although its effective population size is relatively high. Only a weak population structure was observed over the small distribution range of A. pedemontana, resulting from an isolation-by-distance pattern of gene flow. In contrary, A. cebennensis individuals clustered in three populations according to their geographic distribution. Despite this and a larger distribution, the overall genetic diversity was even lower for A. cebennensis than for A. pedemontana. A demographic analysis demonstrated that both endemics have undergone a strong population size decline in the past, without recovery. The more drastic decline observed in A. cebennensis partially explains the very small effective population size observed in the present population. In light of these results, we discuss the adaptive potential of these endemic species in the context of rapid climate change.

Genomics↗

bioRxiv2016

Predicting Drug Synergy and Antagonism from Genetic Interaction Neighborhoods

Although drug combinations have proven efficacious in a variety of diseases, the design of such regimens often involves extensive experimental screening due to the myriad choice of drugs and doses. To address these challenges, we utilize the budding yeast Saccharomyces cerevisiae as a model organism to evaluate whether drug synergy or antagonism is mediated through genetic interactions between their target genes. Specifically, we hypothesize that if the inhibition targets of one chemical compound are in close proximity to those of a second compound in a genetic interaction network, then the compound pair will exhibit synergy or antagonism. Graph metrics are employed to make precise the notion of proximity in a network. Knowledge of genetic interactions and small-molecule targets are compiled through literature sources and curated databases, with predictions validated according to experimentally determined gold standards. Finally, we test whether genetic interactions propagate through networks according to a \"guilt-by-association\" framework. Our results suggest that close proximity between the target genes of one drug and those of another drug does not strongly predict synergy or antagonism. In addition, we find that the extent to which the growth of a double gene mutant deviates from expectation is moderately anti-correlated with their distance in a genetic interaction network.

Systems Biology↗

bioRxiv2016

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

MotivationLD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional categories, and estimate the genetic correlation between different phenotypes. Because the method relies on summary level results data, LD score regression is computationally tractable even for very large sample sizes. However, publicly available GWAS summary-level data are typically stored in different databases and have different formats, making it difficult to apply LD score regression to estimate genetic correlations across many different traits simultaneously.\n\nResultsIn this manuscript, we describe LD Hub - a centralized database of summary-level GWAS results for 177 diseases/traits from different publicly available resources/consortia and a web interface that automates the LD score regression analysis pipeline. To demonstrate functionality and validate our software, we replicated previously reported LD score regression analyses of 49 traits/diseases using LD Hub; and estimated SNP heritability and the genetic correlation across the different phenotypes. We also present new results obtained by uploading a recent atopic dermatitis GWAS meta-analysis to examine the genetic correlation between the condition and other potentially related traits. In response to the growing availability of publicly accessible GWAS summary-level results data, our database and the accompanying web interface will ensure maximal uptake of the LD score regression methodology, provide a useful database for the public dissemination of GWAS results, and provide a method for easily screening hundreds of traits for overlapping genetic aetiologies.\n\nAvailability and implementationThe web interface and instructions for using LD Hub are available at http://ldsc.broadinstitute.org/

Bioinformatics↗

bioRxiv2016

Uplift and erosion of genomic islands with standing genetic variation

Details of the processes that generate biological diversity have long been of interest to evolutionary biologists. A common theme in nature is diversification via divergent selection with gene flow. Empirical studies on this topic find variable genetic differentiation throughout the genome, that genetic differentiation is non-randomly distributed, and that loci of adaptive significance are often found clustered together within \"genomic islands of divergence\". Theoretical models based on new mutations show how these genomic islands can arise and grow as a result of a complex interaction of various evolutionary and genic processes. In the current study, I ask if such genomic islands can alternatively arise from divergent selection from standing genetic variation and I tested this using a simple two locus model of selection. There are numerous ways in which standing genetic variation can be partitioned (e.g., between alleles, between loci, and between populations) and I tested which of these scenarios can give rise to an island pattern compared to no genomic differentiation or complete genomic differentiation. I found that divergent selection, even without reciprocal gene exchange between populations, following a bout of admixture can relatively quickly produce an island pattern. Moreover, I found two pathways in which islands can form from divergence from standing variation: 1) through the build up of islands and 2) through the breakdown of larger, genome-wide differentiation. Lastly, similar to new mutation theory, I found that the frequency of recombination is an important determinant of island formation from standing genetic variation such that mating behavior of a species (e.g., facultative or obligate sexual) can impact the likelihood of island formation.

Evolutionary Biology↗