Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling.

Salvi, J.; Nedelec, E.; Leret, L.; Lienard, F.; Landre, T.; Ben Fradj, S.; Garcia, V.; Gigot, V.; Patris, B.; Pires, V.; Polizzi, A.; Sanchez, C.; Gautier, T.; Guillou, H.; Heurtaux, T.; Petrilli, V.; Blouet, C.; Heneka, M. T.; Rassendren, F.; Rovere, C.; Audinat, E.; Hirbec, H. E.; Compan, V.; Trompier, D.; Benani, A.

doi:10.64898/2026.10.04.756524

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bioRxiv · 10.64898/2026.10.04.756524

Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling.

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Abstract

Reactive microglia are commonly considered neurotoxic and detrimental for brain functioning. Chronic consumption of a high-fat diet strongly activates microglia, disrupts the central control of energy metabolism, contributes to obesity, and promotes cognitive decline. In this study we report an unexpected beneficial function of microglia reaction at the time scale of a meal, whereby they promote satiety in a macronutrient-dependent manner. We show that murine microglia react to ingested dietary fat within three hours. Specifically, postprandial hypertriglyceridemia induced microglial hyper-ramification alongside with a transcriptional reprogramming promoting communication with neurons. This effect occurs in discrete brain areas, including the hypothalamus and the brainstem, which control hunger. Remarkably, microglia-specific genetic ablation of Apoptosis-associated Speck-like protein containing a CARD (named ASC), a master regulator of metabolism, immune function and cell shape, profoundly alters satiety following high-fat food consumption. These results reveal that microglia engage an immune signaling pathway to rapidly alert the neural circuits and activate an anorectic response that limits overconsumption of dietary fat. Unexpectedly, this regulatory process is sexually dimorphic, present in males only. Furthermore, we found that the postprandial microglial reaction is bypassed during obesity, providing a new therapeutic target to treat maladaptive eating disorders.

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Salvi, J., Nedelec, E., Leret, L., Lienard, F., Landre, T., Ben Fradj, S., Garcia, V., Gigot, V., Patris, B., Pires, V., Polizzi, A., Sanchez, C., Gautier, T., Guillou, H., Heurtaux, T., Petrilli, V., Blouet, C., Heneka, M. T., Rassendren, F., Rovere, C., Audinat, E., Hirbec, H. E., Compan, V., Trompier, D., Benani, A.. 2026-10-13. Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling.. https://doi.org/10.64898/2026.10.04.756524

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