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bioRxiv · 10.64898/2026.09.29.755422

Chemogenetic Hydrogen Sulfide Rescues Vascular Senescence in Ageing

Shabanian, K.·Shabanian, T.·Da Dalt, L.·Colucci, M.·Eroglu, E.·Rodriguez Cetina Biefer, H.·Dzemali, O.·Hermann, M.·Alimonti, A.·Norata, G. D.·Paneni, F.·Ruschitzka, F.·Saeedi Saravi, S. S.
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Abstract

Vascular senescence is a central driver of whole-body ageing, yet rescue strategies remain limited. Here we show that hydrogen sulfide (H2S) bioavailability declines in ageing and atherosclerosis and is associated with endothelial senescence. Developing a novel remote-control, endothelial-specific, mitochondria-targeted chemogenetic system, we spatiotemporally controlled H2S generation and thereby mitigated endothelial senescence-driven programs and reversed vascular remodeling in aged mice.

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Shabanian, K., Shabanian, T., Da Dalt, L., Colucci, M., Eroglu, E., Rodriguez Cetina Biefer, H., Dzemali, O., Hermann, M., Alimonti, A., Norata, G. D., Paneni, F., Ruschitzka, F., Saeedi Saravi, S. S.. 2026-09-30. Chemogenetic Hydrogen Sulfide Rescues Vascular Senescence in Ageing. https://doi.org/10.64898/2026.09.29.755422

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