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bioRxiv · 10.64898/2026.09.21.753287

The claustrum encodes and scales appetitive feeding

de Almeida, C.·Mashhour, N.·Bertrand, B.·Ansoult, A.·Castel, J.·Luquet, S.·Gangarossa, G.
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Abstract

The claustrum regulates reward processing, but its role in feeding remains unknown. We report that palatable food recruits claustral neurons and a claustrum-to-medial prefrontal cortex circuit whose activation reduces high-fat diet intake. These findings identify the claustrum as a key regulator of appetitive feeding, with potential implications for metabopsychiatric disorders.

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de Almeida, C., Mashhour, N., Bertrand, B., Ansoult, A., Castel, J., Luquet, S., Gangarossa, G.. 2026-09-28. The claustrum encodes and scales appetitive feeding. https://doi.org/10.64898/2026.09.21.753287

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