Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats

Turner, C. A.; Morales Pagan, N.; Pereira, D.; Sun, E. Y.; Himelhoch, R. E.; Chang, S. E.; Flagel, S. B.

doi:10.64898/2026.09.21.753157

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bioRxiv · 10.64898/2026.09.21.753157

Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats

Turner, C. A.·Morales Pagan, N.·Pereira, D.·Sun, E. Y.·Himelhoch, R. E.·Chang, S. E.·Flagel, S. B.

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Abstract

Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests. Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming. These findings support further investigation of semaglutide as a treatment for cocaine use disorder.

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Turner, C. A., Morales Pagan, N., Pereira, D., Sun, E. Y., Himelhoch, R. E., Chang, S. E., Flagel, S. B.. 2026-09-28. Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats. https://doi.org/10.64898/2026.09.21.753157

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