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bioRxiv · 10.64898/2026.09.20.752968

Human body-site-stratified fungal genomic catalogs enhancing human mycobiome analysis

Ahn, S.·Kim, J.·Lee, I.
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Abstract

Current human mycobiome profiling relies largely on marker-based methods with limited sensitivity, whereas genome-based approaches require computationally intensive alignment against broad fungal references. Here, we present MycobiomeDB, a unified fungal genome catalog, and derive body-site-specific catalogs for the gut, oral cavity, skin, and vagina through metagenome-guided stratification. Using these catalogs, we developed site-specific MycoProfilers that improved taxonomic recall and better distinguished disease-associated mycobiomes from healthy controls than existing methods.

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Ahn, S., Kim, J., Lee, I.. 2026-09-21. Human body-site-stratified fungal genomic catalogs enhancing human mycobiome analysis. https://doi.org/10.64898/2026.09.20.752968

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