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bioRxiv · 10.64898/2026.09.17.752502

EEG Functional Connectivity Reveals Accelerated Brain Aging in Young Adults with Cognitive Deficits and Mental Health Conditions

Phang, C.-R.·Miao, G.-D.·Cai, L.-T.·Rao, H.-Y.·Du, J.-X.
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Abstract

The discrepancy between chronological age and predicted brain age, derived from neuroimaging data, serves as a biomarker for neurological health. However, the exact electroencephalography (EEG) mechanisms contributing to the variation of brain age are yet to be understood. This paper comprehensively investigated the relationship between brain age estimated from EEG-based functional connectivity and cognitive or mental manifestations of healthy adults. A mean absolute error (MAE) of 5.97 and R-squared (R2) of 0.85 were reported for training data, while an MAE of 10.73 and R2 of 0.56 were reported for the prediction data. Increased brain age was found to be negatively related to the scores of memory and attention tasks. Most young adults (19 of 26) suffering from mental symptoms such as addictions, depression, phobia, and anorexia nervosa demonstrated higher brain age than their chronological age. Alcohol consumption was also significantly correlated to the difference between brain and chronological ages. The functional connectivity of frontal and central motor regions was found to be most distinguishing between individuals with high and low brain ages. These brain regions were significantly correlated with brain age but not chronological age, suggesting a relatively stronger relationship with biological age. Ablation studies further confirmed the importance of the frontal brain and all bands EEG in the prediction of brain age. This work advances the understanding of EEG mechanisms contributing to brain age and could provide an interpretation for physiological or psychological conditions associated with brain age.

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Phang, C.-R., Miao, G.-D., Cai, L.-T., Rao, H.-Y., Du, J.-X.. 2026-09-24. EEG Functional Connectivity Reveals Accelerated Brain Aging in Young Adults with Cognitive Deficits and Mental Health Conditions. https://doi.org/10.64898/2026.09.17.752502

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