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bioRxiv · 10.64898/2026.08.24.746689

Distinct and overlapping correlates of fear acquisition and extinction across different neuroimaging modalities

Gabdulkhakov, A.·Fraenz, C.·Metzen, D.·Packheiser, J.·Merz, C. J.·Axmacher, N.·Genc, E.
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Abstract

Interindividual differences in fear acquisition and extinction have been related to variation in specific brain correlates. However, variability in experimental setups complicates the integration of findings. Here, we present a combined fear acquisition (n = 101) and extinction (n = 88) study from which we obtained distinct microstructural, macrostructural, and connectivity brain properties with magnetic resonance imaging in healthy, young participants. The properties included regional brain volume, cortical surface area and thickness, neurite density and orientation dispersion, and nodal efficiency of structural and functional connectivity. Fear responses were quantified as changes in skin conductance. Data from 360 cortical and 16 subcortical brain regions as well as the efficiency of network connections between them were used as independent variables in bootstrapped and cross-validated regularized regression models. Results show that numerous brain regions, spanning the so-called 'fear and extinction network' and extending beyond it, contribute to fear acquisition, to extinction, or dynamically shift between both phases. For several brain regions, data from multiple imaging modalities showed a high degree of concordance for several brain regions. These findings call for further research to examine the potential interplay between brain correlates shaping fear acquisition and extinction, as opposed to studying the imaging modalities in isolation.

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Gabdulkhakov, A., Fraenz, C., Metzen, D., Packheiser, J., Merz, C. J., Axmacher, N., Genc, E.. 2026-08-27. Distinct and overlapping correlates of fear acquisition and extinction across different neuroimaging modalities. https://doi.org/10.64898/2026.08.24.746689

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